Anti-Malarial ADEs

Question 1

ADE Chloroquine?

Answer 1

Toxic to eyes (binds to melanin), Ototoxic, Peripheral neuropathy.

(Skin, Hair, Blood, Eyes)

Question 2

ADE Quinine?

Answer 2

Cinchonism (Tinnitus, blurred vision, hearing loss), Cardiodepression, Uterine contraction

Question 3

ADE Quinidine Gluconate?

Answer 3

Anti-cholinergic effects

Question 4

ADE Mefloquine?

Answer 4

Vertigo, visual disturbances, Nightmares, Contraindicated with beta-blockers, seizures

Question 5

ADE Lumefantrine?

Answer 5

Increased QT interval, CYP3A4 interactions

Question 6

ADE Artemisinins?

Answer 6

Brain, Liver, Marrow, Fetus.

Question 7

ADE Primaquine?

Answer 7

G6PD, Methemaglobinemia

Question 8

ADE Pyramethamine?

Answer 8

Rash, Marrow suppression, Megaloblastic anemia.

Question 9

ADE Bendazoles?

Answer 9

Teratogenic

Question 10

ADE Pyrantel pamoate?

Answer 10

No significant ADEs

Question 11

ADE Ivermectin?

Answer 11

Pruritis, Dizziness, +/- allergic reaction to dying worms

Question 12

Diethylcarbamazine ADE?

Answer 12

Host reaction to dying bugs

Question 13

Praziquantel ADE?

Answer 13

Contraindicated in ocular schistomiasis