Anti-Neoplastic Drugs Flashcards Preview

CMBM E4 CB > Anti-Neoplastic Drugs > Flashcards

Flashcards in Anti-Neoplastic Drugs Deck (10):
1

Cyclophosphamide toxicities

Cardiotoxicity
Hemorrhagic cystitis
"Bladder Burn" or hematuria

2

Methotrexate mechanism

Analog of folic acid
Competitively inhibits dihydrofolate reductase (blocks dTMP synthesis required for DNA synthesis)

3

Leucovorin function

Folinic acid that does not require dihydrofolate reductase
Decreases effect of methotrexate

4

5-flurouracil mechanism

Blocks thymidylate synthatase
Can incorporate into RNA and interfere w/ processing
Can incorporate into DNA and inhibit synthesis

5

5-FU toxicities

Severe ulceration of oral and GI mucosa
Diarrhea

6

Mercaptopurine mechanism

Causes DNA breaks

7

What is critical for 6-Mercaptopurine activation?

HGPRT

8

What is Mercaptopurine used to treat?

Leukemia in children

9

Imatinib mechanism

Inhibits constitutively active Bcr-Abl tyrosine kinase
Competes with ATP for binding to the kinase domain of Bcr-Abl

10

Imatinib administration

Continuous