Flashcards in Anti-Neoplastic Drugs Deck (10):
"Bladder Burn" or hematuria
Analog of folic acid
Competitively inhibits dihydrofolate reductase (blocks dTMP synthesis required for DNA synthesis)
Folinic acid that does not require dihydrofolate reductase
Decreases effect of methotrexate
Blocks thymidylate synthatase
Can incorporate into RNA and interfere w/ processing
Can incorporate into DNA and inhibit synthesis
Severe ulceration of oral and GI mucosa
Causes DNA breaks
What is critical for 6-Mercaptopurine activation?
What is Mercaptopurine used to treat?
Leukemia in children
Inhibits constitutively active Bcr-Abl tyrosine kinase
Competes with ATP for binding to the kinase domain of Bcr-Abl