Anti Parasitics

Question 1

tx tripanosoma gambiencie/ brucei

Answer 1

suramin
melasoprostol
pentamidine

Question 2

tx trypanosoma cruzi

Answer 2

nifurtimox [knee high fur socks]

Question 3

tx Leishmaniasis

Answer 3

stibogluconate [t bone steak]

miltefosine-

Question 4

tx of giarda

Answer 4

metronidazole

quacrine-

Question 5

tx trichomoniasis

Answer 5

metronidazole

Question 6

family of metronidazole and mechanism

Answer 6

tinidazole
(anaerobic and parasitic)
disrupts DNA 3ary structure

Question 7

tx for amiebiasis

luminal amebicides

Answer 7

metronidazole
iodoqionol [queen iodos tomb]
paromomycin [pair of mice]

Question 8

tx amebiasis

systemic amebicides

Answer 8

emetine

dehydroemetine

Question 9

tx for toxoplasmosis

Answer 9

pyrimethamine [pyramid shaped eggs],
sulfadiazine [sulfa dyed eggs] - s
atoquavone -

Question 10

mechanism nifurtimox

Answer 10

T. cruzi

• produces intracellular free radicals that kill organism *

Question 11

miltefosine

mech

Answer 11

leishmaniasis

- bind to parasitic dna

Question 12

metronidazole

mech

Answer 12

giardia
amebiasis
trichomoniasis
- bind to protein and dna

Question 13

quacrine

mech

Answer 13

giardia

-binds to membrane phospholipids

Question 14

systemic amebicides mech

Contraindicated

Answer 14

emetine
dehydroemetine

block chain elongation of proteins

Contraindicated in pregnancy cause cardiotoxicity

Question 15

pyrimethamine
sulfadiazine
mech

Answer 15

toxoplasmosis

• inhibits folate synthesis

Question 16

atovaquone

mech

Answer 16

toxoplasmosis
PCP
- inhibits mitochondrial ETC

Question 17

tx PCP

Answer 17

TMP SMZ* best one
pentamidne
atovaquone
dapsone— in AIDS patients

Question 18

malaria

drug of choice for which one

Answer 18

plasmodium falcifarum- primaquine

vivax, ovale, malarial– chloroquine quinine

Question 19

malaria tx

erythricytic cycke

Answer 19

slow
-cloroquine
-quinidine
-mefloquine
fast
- proguanil
- pyrimethamine

Question 20

malaria tx

exoerythocrytic stage

Answer 20

chloroguanide (proquanil)

or pyrimethamine

Question 21

quinine mechanism

Answer 21

used for resistant strains of malaria

affects dna synthesis

Question 22

effects quinine

Answer 22

Cinchonism: hearing visual cna

over dose abortion

Question 23

chloroguanide (proguanil)

mechanism

Answer 23

malaria
inhibits DHF reducatase
used with chloroquine in prophylaxis

Question 24

artemether

mechanism

Answer 24

inhibits DNA and protein synthesis

Was found in worm wood

Question 25

best tx for malaria

Answer 25

combination of atovaquone and proguanil

Question 26

tx for nematodes

Answer 26

roundworms | mebendazole

Question 27

mechanism for mebendazole

Answer 27

inhibits microtubule synthesis of parasite | ascaris, enterobius, necator, ancylostoma, trichuris

Question 28

tx for filariasis

Answer 28

wurcheria bancrofti diethylcarbamazine

Question 29

tx for flatworms

Answer 29

praziquantel | niclosamide

Question 30

tx for trematodes and cestodes

Answer 30

praziquantel

Question 31

mechanism of praziquantel

Answer 31

increases calcium permeability and paralyses worm musculature

Question 32

Mechanism | Melasoprostol

Answer 32

T. Brucei Inhibits parasitic enzymes by binding to sulfhydril groups

Question 33

Proguanil and pyrimethamine | Mech

Answer 33

Inhibit plasmodial dihydrofolate reductase

Question 34

Primaquine | Mech

Answer 34

Malaria Inhibits plasmodial dna replication One that’s used in relapses in p vivax and ovale

Question 35

Praziquantel CI

Answer 35

in cysticercosis of eye | Can damage eye