Anti-platelet drugs Flashcards Preview

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Flashcards in Anti-platelet drugs Deck (26):
1

What are some examples of anti-platelet drugs?

Glycoprotein IIb/IIIa inhibitors
ADP receptor antagonists

2

What are some examples of glycoprotein (GP) IIb/IIIa drugs?

Eptifibatide
Abciximab

3

How is eptifibatide administered?

IV

4

For what is eptifibatide given?

ACS
PCI/stent

5

What is the GP IIb/IIIa drug abciximab?

A chimeric monoclonal antibody
*human/murine

6

What is a concern about abciximab and what is the result of this?

Numerous adverse effects
Little used

7

What is an example of an ADP antagonist?

Ticlopidine

8

What adverse effects caused the the black box warning for ticlopidine?

Neutropenia
Agranulocytosis
Thrombotic thrombocytopenia purpura
Aplastic anemia

9

What is ticlopidine reserved for?

Patients who are intolerant to aspirin or have failed aspirin therapy

10

What is a common ADP antagonist?(think Katy's lectures)

Clopidogrel (plavix)

11

What is clopidogrel?

A prodrug converted to an unidentified active metabolite

12

What is the ultimate result of clopidogrel?

Preventing platelet aggregation

13

What affect does clopidogrel have on PPIs?

Decreased activity of PPI by CYP 2C19 inhibition

14

What affect do PPIs have on clopidogrel?

Increased risk of re-stenosis

15

What ADP antagonist is considered more effective than clopidogrel and ticlopidine?

Prasugrel

16

What is an advantage prasugrel has over clopidogrel?

Less inhibition by PPIs

17

What is a classic platelet antagonist?

Aspirin

18

What is the MOA of aspirin?

Inhibits platelet aggregation by acetylation of ADP receptor

19

How long does acetylation via aspirin last?

The life of the platelet

20

What are some adverse effects of aspirin?

GI bleed
Tinitis

21

What do we consider with adverse effects of aspirin and how can we avoid them?

Benefits vs. adverse effects
Minimal at low doses

22

What type of aspirin do you give for an acute MI?

Normal -> not baby aspirin

23

What kind of drug is dipyridamole?

Platelet antagoinst

24

What are the mechanisms of dipyridamole?

Platelet aggregation inhibitor
Vasodilator

25

Under what condition do you combine dipyridamole with another drug and what drug do you combine it with?

When pt has a mechanical heart valve
Warfarin

26

When is dipyridamole used as a diagnostic agent?

In CAD
Persasntine stress test