Anti Platelet----EXAM2 Flashcards
(26 cards)
Irreversible inh of platelet cyclooxygenase
Long DOA: 6-10 days
Aspirin
Revesible inh of platelet cyclooxygenase inh
Short DOA
NSAID
IND
cyclooxygenase inh
Inhib clot formation in coronary or cerebral arteries
Anti-inflam
Anti-pyretic
Contra IND
Cyclooxygenase inh
Active GI ulcer, bleeding disorder,
Children
INT
Cyclooxygenase inh
Warfarin
Methotrexate
Valproic acid
AD
Cyclooxygenase inh
GI bleeding
Upset stomach
Tinnitus w high levels
Also nausea, vomiting, heart burn
Decrease risk of MI
Aspirin
Can cause gastric ulcers if large dose for long period -> can be prevented by enteric coating
Aspirin, NSAID
MOA
Selective ADP inh
Inh ADP receptors on the surface of platelets
- prevent expression of GP IIb/IIIa receptors
- prevent ADP-induced platelet aggregation
Selective ADP inh
Thiebopyridine class - irreversible ADP inh
Non- thienopyridine - reversible ADP inh
Thiebopyridine class - irreversible ADP inh
Ticlopidine
Clopidogrel
Prasugrel
AD
Ticlopidine
Neutropenia, thrombocytopenia, rash
Diarrhea
AD
Clopidorel -proton pump inh
Rash, diarrhea, bleeding
INT
Clopidogrel
Aspirin, warfarin, NSAID
IND
Prasugrel- potent, quick onset
Dec MI
AD
Prasugrel
High incidence of bleeding
IND
Ticagrelor
Prevents mortality in MI
Reversible, so give it multiple times a day
AD
Ticagrel
Short of breath
Dyspnea
Bentricular pause
Cyclooxygenase inh
Aspirin, NSAID
Angiotensin Ii
Vasoconstircts,
Inc aldosterone synthesis
ACEI (angiotensin converting enzyme inhibitor)
All are prodrug except captopril, lisinopril, enalaprilat
Moexipril- prodrug
MOA
ACEI (angiotensin converting enzyme inhibitor)
Inhibit conversion of angiotensin I to angiotensin II (blocks vasoconstiction)
Inhibit degradation of bradykinin
IND
ACEI (angiotensin converting enzyme inhibitor)
Hypertension L ventr heart failure Post MI Hypertensive crisis Captopril test Raynaud's ds
Contra IND
ACEI (angiotensin converting enzyme inhibitor)
Pregnancy(2nd, 3rd trimester)
Renal a stenosis
