Anti-Protist & Anti-Helminth

Question 1

Parasites are a complex organism

Answer 1

True

Question 2

Protist one-celled organisms

Answer 2

True

Question 3

Helminths are parasitic worms and are much larger than?

Answer 3

Protists

Question 4

Antiparasitic drugs are not known to be toxic.

Answer 4

False

Question 5

Malara caused by

A. Mosquito
B. P. vivax
C. P. ovale
D. All of the above

Answer 5

D. All of the above

Question 6

The zygote form into an oocyst which will release what?

Answer 6

sporozoites

Question 7

Do sporozoites multiply sexually or asexually?

Answer 7

Asexually

Question 8

Where does the malarial infection take hold?

Answer 8

In the liver

Question 9

What invades the erythrocytes?

Answer 9

Merozoites

Question 10

T or F: P. falciparum causes the blood cells to stick together due to the knobs that grow on their surface

Answer 10

True

Question 11

The drugs act at what stage?

Answer 11

Blood schizont

Question 12

Where do malarial plasmodia get their amino acids from?

Answer 12

From the hemoglobin by digesting it

Question 13

Free Heme is not toxic

Answer 13

False

Question 14

Hemozoin is not toxic

Answer 14

True

Question 15

Quinoline is a natural drug that prevetnts tthe detoxification of toxic free heme. What drugs are like it?

A. Chloroquine
B. Quinine or Quinidine
C. Artemisinin
D. All of the above

Answer 15

D. All of the above

Question 16

The mutation found that a transporter pumps out the chloroquine is found in which disease?

Answer 16

Malaria

Question 17

ACT is ?

Answer 17

Artemisinin Combination Therapy, the first line treatment of malaria

Question 18

DHOD performs a key step to make?

Answer 18

Pyrimidine synthesis

Question 19

Atovaquone and Primaquine are related to ubiquinone and shuts down?

Answer 19

pyrimidine nucleotide biosynthesis, so no DNA or RNA and kills parasite.

Question 20

Doxycycline, and tetracycline, clindamycin are used in?

Answer 20

Combination of malarial drugs.

Question 21

Amebiasis are

Answer 21

Amebozoas.

Examples: E. histolytica

Question 22

Metronidazole is a prodrug targeting what ?

Answer 22

Membranes of parasites

Question 23

Metrodinazole is active by ?

Answer 23

Ferrodoxin

Question 24

Metronidazole has been shown some resistance to which organism ?

Answer 24

Giardia, parasite found in contaminated food and water.

Question 25

Trypanosomiasis is caused by

Answer 25

Trypanosomiasis brucei, a protist.

Question 26

Leishmaniasis is caused by

Answer 26

Leishmania. A small bite from a sandfly.

Question 27

Drugs that work against trypanosome and has a high affinity for mtDNA OF THE KINETOPLASTIDS of which blocks it’s DNA replication?

Answer 27

Pentamindine

Question 28

Drugs that works against trypanosome that binds the protein and lipids to inhibit metabolism.

Answer 28

Suramin

Question 29

Drugs that work against trypanosome inhibits pyruvate kinase which is used in ?

Answer 29

Melarsprol and pyruvate kinase is used in glycolysis

Question 30

Drugs that work against trypanosome less toxic alternative to melarsoprol ?

Answer 30

Eflornithine

Question 31

Helminth infections are parasitic ______?

Answer 31

Worms

Question 32

``` River blindness is cause which organism A. E. Histolyica B. Gardisia C. P. Vivax D. O. volvulus ```

Answer 32

D. O. volvulus

Question 33

What is the most famous anti parasitic drug ?

Answer 33

Ivermectin

Question 34

What drug binds to the channels of the nerve and muscle cells ?

Answer 34

Ivermectin

Question 35

What drug causes constant open of the channels in the absence of glutamate ?

Answer 35

Ivermectin

Question 36

Another drug to treat helminths is called ?

Answer 36

Microtubule inhibitors

Question 37

T or F Nematode beta tubulin is similar to human beta tubulin.

Answer 37

False, they are sufficiently different.

Question 38

Inhibitors of plasmodia electron transport

Answer 38

Atova and prima

Question 39

Which two combo drugs are not used because parasite are resistant to the drug

Answer 39

Sulfa and pyrimeethamine

Question 40

Most eukaryotes lack the fermentation enzyme ?

Answer 40

PFOR

Question 41

Low resistance in parasites is due to few ____________ alternatives

Answer 41

Metabolic