Anti-Psychotic Drugs

Question 1

What are Anti-Psychotic Drugs used to treat?

Answer 1

Psychoses, Schizophrenia, autism, mania, BPD, certain movement disorders, nausea and intractable hiccups, aggression

Question 2

Two classes of Anti-Psychotic Agents

Answer 2

Typical (conventional, 1st gen) and atypical (novel, 2nd gen)

Question 3

aripiprazole

Answer 3

Abilify. Indications: Schizophrenia and related psychotic disorders, Acute manic or mixed episodes in BPD

Question 4

asenapine

Answer 4

Saphris. Indications: Schizophrenia, Bipolar acute mania/mixed.

Question 5

brexpiprazole

Answer 5

Rexulti. Indications: Schizophrenia, Adjunctive MDD

Question 6

clozapine

Answer 6

used for schizophrenia (treatment-resistant). May reduce the risk of suicidality.

Question 7

lurasidone

Answer 7

Latuda. Indications: Schizophrenia (15 to 17), Depressive episodes associated with Bipolar 1 Disorder in 13 to 17.

Question 8

olanzapine

Answer 8

Zyprexa, Zydis. Indications: Schizophrenia and related psychiatric disorders, Bipolar 1 disorder maintenance

Question 9

paliperidone

Answer 9

Invega Sustenna, Trinza. Indications: Schizophrenia and related psychotic disorders. Trinza is used after at least 3 months of Sustenna.

Question 10

quetiapine

Answer 10

Seroquel. Indications: Schizophrenia acute and maintenance, Bipolar Depression, Bipolar disorder acute mania/mixed.

Question 11

risperidone

Answer 11

Risperdal (IM, tabs, oral). Indications: Schizophrenia (maintenance), severe Dementia short term for aggressive and psychotic behaviours, Bipolar disorder Acute mania/mixed.

Question 12

ziprasidone

Answer 12

Zeldox. Indications: Schizophrenia and related psychotic disorders, acute mania or mixed episodes associated with bipolar 1 disorder, Dementia Aggression in Elderly.

Question 13

Tardive Dyskinesia

Answer 13

involuntary movements that range from mild to disabling or even life-threatening

Question 14

Signs of TD (Facial and Head)

Answer 14

backward-forward tongue curling, chewing cheek and jaw, smack or pucker lips, increased rapid blinking or screwing shut their eyes

Question 15

Signs of TD (Neck & Trunk)

Answer 15

Difficulty swallowing, irregular respiration and grunting, irregular twisting, turning shoulders and thrusting hips. Retrocollis, and spasmodic torticollis.

Question 16

Signs of TD (Body and extremities)

Answer 16

Irregular jerky or writhing movements of arms, hands, fingers, legs and feet. Fluttering movements (piano or guitar playing, peculiar awkward gait.

Question 17

Neuroleptic Malignant Syndrome

Answer 17

Medical emergency and requires immediate treatment. A rare and potentially fatal adverse effect of antipsychotic agents and various other medications. Can occur 3 to 9 days after starting meds

Question 18

Signs and Symptoms of NMS

Answer 18

exposure to dopamine-blocking agent, fever, severe muscle rigidity, diaphoresis, dysphagia, tachycardia, changes in consciousness ranging from confusion to coma, tremor, incontinence, mutism, elevated or labile blood pressure, leukocytosis, dyspnea or tachypnea