Anti-psychotics

Question 1

major tranquilizers

Answer 1

anti-psychotics/neuroleptics

Question 2

minor tranquilizers

Answer 2

benzodiazepines and barbiturates

Question 3

hallmark of schizophrenia

Answer 3

senses clear but thinking disrupted

Question 4

positive symptoms of schizophrenia

Answer 4

1. hallucinations
2. delusions
3. bizzare behavior
4. thought disorder

Question 5

negative symptoms of schizophrenia

Answer 5

1. anhedonia
2. alogia
3. lack of attention
4. flattening of expressions

Question 6

typical anti-psyhcotics

Answer 6

*phenothiazines

*aliphatic derivatives
1. chloropromazine
2. promazine

• piperadines
  3. thioridazone
  4. mesoridazone
• piperazines
  5. procholroperazine
  6. fluphenazine

* butyrophenones
1. haloperidol
2. droperidol

* thioxanthines
1. chloroprothixene
2. clopenthixol
3. flupenthixol

Question 7

atypical neuroleptics

Answer 7

1. Aripripazole
2. Clozapine
3. Olanzapine
4. Ziprasidone

Question 8

positive symptoms caused by which pathways

Answer 8

mesolimbic and nigrostriatal

Question 9

negative symptoms caused by which pathways

Answer 9

mesocortical and tuberoinfundibular

Question 10

aim of treatment of postive symptoms

Answer 10

slow down dopamine transmission

Question 11

aim of treatment of negative symptoms

Answer 11

increase dopamine transmission

Question 12

serotinin receptor agonists

Answer 12

1. LSDs
2. Mescaline

Question 13

5ht agonists stimulate what receptors

Answer 13

1. 5-HT2A
2. 5-HT2C

Question 14

serotonin agonists propagate which symptom of schizophrenia

Answer 14

+ Hallucinogenic symptoms

Question 15

inhibitors of NMDA receptors on GABA

Answer 15

1. Phencyclidine
2. Ketamine

Question 16

primary mechanism of action of neuroleptics

Answer 16

blockage of dopamine receptors (mainly D2)

Question 17

Blocakge of medullary-paraventricular pathway

Answer 17

increased appetite and weight gain

Question 18

blockage of nigrostriatal pathway

Answer 18

movement disorders

Question 19

blockage of tuberoinfundibular pathway

Answer 19

hyperprolactinemia

Question 20

other receptors blocked by antitpsychotics

Answer 20

1. serotonin
2. alpha I and II
3. histamine
4. muscarinic

Question 21

positive symptoms treated by

Answer 21

typical anti-psychotics

Question 22

negative symptoms treated by

Answer 22

atypical antipsychotics

Question 23

anti-muscarinic effects of anti-psychotics

Answer 23

1. dry mouth
2. constipation
3. urinary retention
4. blurred vision

Question 24

anti-apha receptor effects of anti-psychotics

Answer 24

1. postural hypotension
2. reflex tachycardia
3. sexual dysnfunction

Question 25

major therapeutic use of antipsychotics

Answer 25

schizophrenia

Question 27

minor therapeutic uses

Answer 27

1. psychosis (drug-induced and senile) 2. tourette's 3. alzhiemers 4. anxiety

Question 28

adverse effects of antipsychotics

Answer 28

1. EP effects 2. Neuroleptic malignant syndrome 3. dystonia 4. parkinsonism 5. tardive dyskinesia 6. aakathisia 7. gynaeconmastia 8. hyperprolactinemia in females (leads to infertiliy)

Question 29

high potency neuroleptics

Answer 29

1. piperazines 2. haloperidol 3. thioxanthines 4. clozapine

Question 30

low potency neuropleptics

Answer 30

chloropromazine

Question 31

treatment of agitated and violent patients

Answer 31

1. haloperidol 2. chloropromazine

Question 32

treament of manic and elevated mood patients

Answer 32

1. haloperidol 2. fluphenazine