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Flashcards in Antianemic drugs Deck (17)
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1

Where is iron best absorbed?

- Duodenum and proximal jejunum

2

How should iron be taken?

- Not with food, phosphates, tannates and phytate in food bind iron and prevent its absorption.
- 2 hrs before or 4 hrs after antacids
- Iron salt best absorbed in mildly acidic form, 250 mg Vit C or half glass of orange juice.

3

What is iron dextran used for?

- Parenteral, IV or IM
- Must test with small amount for allergies
- Blood loss, IBS, kidney, cancer, heart disease

4

What is ferric gluconate complex used for?

- IV infusion lower incidence of allergy

5

When is iron sucrose used?

- IV only
- Limited to 300mg every 2-3 weeks
- Combined with EPO to prevent anemia in dialysis patients

6

What is ferumoxytal and its use?

- Supermagnetic rion naoparticle
- Rapid IV for kidney disease

7

What is ferric carboxymaltose?

- Stable complex for 15 min IV of 1000mg pre week
- Up to 1500 mg

8

What are the side effects of iron IV?

- Fever, arthralgia, myalgia, constipation, diarrhea, thick green stool
- Self limiting
- Corticosteroids given theraputically
- Inflammation in arthritis patients
- 1-2g fatal in children
- Desferoximine for OD

9

What are the erythrocyte factors?

- Iron
- B 12
- EPO

10

What are the granulocyte factors?

- Filgrastim (G-CSF)
- Sargramostim (GM-CSF)

11

What are the platelet factors?

- Oprelvekin (IL-11)
- Romiplostim
- Eltrombopag

12

What are the two forms of cyanocobalamin in the body and their function?

- Methylcobalamin- HCN--> methionine
- Adenosylcobalamin- Methylmalonyl-Co--> succinyl-Co

13

What are the 3 EPO therapies and there use?

- Erythropoietin
- Darbepoietin
- Methoxy poly ethyl glycol poietin
- Anemias, marrow suppressive therapies, to decrease need for transfusions.

14

What is the primary function of filgrastim?

- Increases neutrophil production and activity

15

What is the primary function of sargramostim?

- More general granulocyte stimulator

16

What is the function of oprelvekin?

- Megakaryocytes--> platelets
- Neutrophils

17

What is the function of Romiplostim and eltrombopag?

- Both bind to thrombopoietin receptor and stimulate platelet production.
- Romiplostim- human antibody fused to peptide
- Eltrombopag- synthetic peptide binds receptor