Flashcards in Antianemic drugs Deck (17)
Where is iron best absorbed?
- Duodenum and proximal jejunum
How should iron be taken?
- Not with food, phosphates, tannates and phytate in food bind iron and prevent its absorption.
- 2 hrs before or 4 hrs after antacids
- Iron salt best absorbed in mildly acidic form, 250 mg Vit C or half glass of orange juice.
What is iron dextran used for?
- Parenteral, IV or IM
- Must test with small amount for allergies
- Blood loss, IBS, kidney, cancer, heart disease
What is ferric gluconate complex used for?
- IV infusion lower incidence of allergy
When is iron sucrose used?
- IV only
- Limited to 300mg every 2-3 weeks
- Combined with EPO to prevent anemia in dialysis patients
What is ferumoxytal and its use?
- Supermagnetic rion naoparticle
- Rapid IV for kidney disease
What is ferric carboxymaltose?
- Stable complex for 15 min IV of 1000mg pre week
- Up to 1500 mg
What are the side effects of iron IV?
- Fever, arthralgia, myalgia, constipation, diarrhea, thick green stool
- Self limiting
- Corticosteroids given theraputically
- Inflammation in arthritis patients
- 1-2g fatal in children
- Desferoximine for OD
What are the erythrocyte factors?
- B 12
What are the granulocyte factors?
- Filgrastim (G-CSF)
- Sargramostim (GM-CSF)
What are the platelet factors?
- Oprelvekin (IL-11)
What are the two forms of cyanocobalamin in the body and their function?
- Methylcobalamin- HCN--> methionine
- Adenosylcobalamin- Methylmalonyl-Co--> succinyl-Co
What are the 3 EPO therapies and there use?
- Methoxy poly ethyl glycol poietin
- Anemias, marrow suppressive therapies, to decrease need for transfusions.
What is the primary function of filgrastim?
- Increases neutrophil production and activity
What is the primary function of sargramostim?
- More general granulocyte stimulator
What is the function of oprelvekin?
- Megakaryocytes--> platelets