Antianginal - Overview Flashcards
(9 cards)
What is the mechanism by which pharmacologic treatments can reduce angina?
The reduction of myocardial oxygen consumption by decreasing one or more of the determinants of oxygen consumption: end diastolic volume, blood pressure, heart rate, contractility, and/or ejection time
Among the calcium channel blocker, which acts most like nitrates in treating angina? Which acts like a blocker?
Nifedipine; verapamil
What are the effects of nitrates, blockers, and a combination of both on end diastolic volume?
Blockers increase end diastolic volume, nitrates decrease end diastolic volume, and a combination of both either has no effect or decreases end diastolic volume
What are the effects of nitrates, blockers, and a combination of both on blood pressure?
Blockers, nitrates, and a combination of both all decrease blood pressure
What are the effects of nitrates, beta blockers, and a combination of both on contractility?
Blockers decrease contractility, nitrates increase contractility (as a reflex response), and a combination of both has little/no effect on contractility
What are the effects of nitrates, blockers, and a combination of both on heart rate?
Blockers decrease heart rate, nitrates increase heart rate (as a reflex response), and a combination of both decreases heart rate
What are the effects of nitrates, blockers, and a combination of both on ejection time?
Blockers increase ejection time, nitrates decrease ejection time, and a combination of both has little/no effect on ejection time
What are the effects of nitrates, blockers, and a combination of both on myocardial oxygen consumption?
Blockers and nitrates decrease myocardial oxygen consumption, but a combination of both severely decreases myocardial oxygen consumption
Which two beta-blockers are contraindicated in angina and why?
Pindolol and acebutolol because they are partial beta-agonists and can increase myocardial oxygen consumption
