Antiarrhythmic

Question 1

1A

Answer 1

Prcainamide(cholinolytic)

Question 2

1B

Answer 2

Lidocaine

Question 3

1C

Answer 3

Ethacizine,propafenon,flecainidine

Question 4

Ethacizine

Answer 4

Class4 property

Question 5

Propafenon

Answer 5

Class2and4property

Question 6

Flecainid

Answer 6

Class 3property

Question 7

2nd class antiarrhythmic

Answer 7

BAB

Question 8

3rd class antiarrhythmic

Answer 8

Amiodarone,sotalol,vernakalant

Question 9

Amiodarone has

Answer 9

1a,2 and4 property

Question 10

Sotalol(3) also has property of

Answer 10

Class 2

Question 11

Vernakalant also has property to

Answer 11

1b

Question 12

Class 4 antiarrhythmic

Answer 12

Verapamil and diltiazem

Question 13

Non classified antiarrhythmic

Answer 13

Magnesium sulphate, Atropine,Digoxin, Epinephrine (MADE)

Question 14

Phase 0 of SAN and AVN is provided by

Answer 14

Depolarisation -calcium flux

Question 15

Phase 3 of SAN and AVN is provided by

Answer 15

Repolarization (K flux)

Question 16

Phase 4 of SAN and AVN is provided by

Answer 16

Both calcium and Na flux(slow diastolic depolarization)

Question 17

Phase 0 of contractile Myocardium and his- purkinje is provided by

Answer 17

Na flux

Question 18

Phase 1 of contractile M is provided by

Answer 18

K flux

Question 19

Phase 2of CM are provided by

Answer 19

Calcium flux

Question 20

Phase 3 of CM and His- purkinje are provided by

Answer 20

K flux

Question 21

Phase 4 is (CM)

Answer 21

Polarization or resting phase

Question 22

Systole happens in

Answer 22

0 to 3 rd phase

Question 23

Diastole happens in

Answer 23

Phase 4

Question 24

Arrythmia are

Answer 24

Change in origin of rhythm, change in HR,change in regularity, disturbance in conduction of impulse

Question 25

Hemodynamics

Answer 25

Rhythm and frequency

Question 26

Class 2 and 4 acts on

Answer 26

Inhibits phase 0 and 4 of SA and AV phases

Question 27

Class 1a inhibits phase

Answer 27

0 and 3 of CM

Question 28

Class 1b and 1c inhibits

Answer 28

Phase 0 of CM

Question 29

Class 3inhibits

Answer 29

Phase 3 of CM

Question 30

Lidocaine only act against

Answer 30

Ventricular arrythmia

Question 31

Calcium channel blockers indication

Answer 31

Only for supraventricular arrythmia

Question 32

ECG of 1a class

Answer 32

QRS and QT prolongation

Question 33

For 1b ecg

Answer 33

QT become short

Question 34

1c ecg

Answer 34

QRS prolongation

Question 35

Dissociation kinetics 1a,b,c

Answer 35

Medium,fast,slow

Question 36

Drug affinity on na channel of 1a and c

Answer 36

Open is more than inactivated

Question 37

Na channels are inactivated during

Answer 37

Phase 1,2 and3

Question 38

Na channels are open in

Answer 38

Phase 0

Question 39

Prcainamide is

Answer 39

Na and K channel blocker

Question 40

Clinical use of prcainamide

Answer 40

Treatment of SVA and VA

Question 41

Side effects of prcainamide

Answer 41

Hypotension, lupus erythematous syndrome, proarryhthmic effect,Torsades de pointes(TdP)

Question 42

Because of fast dissociation kinetics of 1b

Answer 42

No change in QRS complex duration

Question 43

Clinical use of lidocaine

Answer 43

VA treatment

Question 44

Side effects of Lidocaine

Answer 44

CNS toxicity (seizures)

Question 45

Lidocaine has

Answer 45

First pass metabolism

Question 46

Class 1 c use

Answer 46

SVA

Question 47

Side effects of class 1c

Answer 47

Heart failure

Question 48

All class 3 ecg

Answer 48

Prolonged QT interwal

Question 49

Amiodarone is

Answer 49

Na channel blockers, potassium channel blockers,beta blockers and calcium channel blockers

Question 50

Amiodarone doe

Answer 50

1a,3,2,and4 class mechanism

Question 51

In 2 and 4 class mechanism

Answer 51

Negative chronotropy,dromotropy and inotropy happens

Question 52

Negative chronotropy

Answer 52

Increased RR interval

Question 53

Negative dromotropy

Answer 53

Increased PR interval

Question 54

Use of amiodarone

Answer 54

Both SVA and VA

Question 55

Side effects of amiodarone

Answer 55

Hypo or hyperthyroidism,pneumofibrosis, photo toxicity, hepatotoxicity,blue skin pigmentation (smurf skin),corneal deposition, rarely Tdp

Question 56

Amiodarone toxicity

Answer 56

Bradyarrythmia , ventricular arrythmia

Question 57

Amiodarone is structural similar to

Answer 57

Thyroxine

Question 58

Major life threatening toxicity of amiodarone

Answer 58

Pulmonary toxicity

Question 59

Amiodarone toxicity treatment

Answer 59

QRS prolongation, bradyarrythmia and hypotension can be treated by sodium bicarbonate Torsades de pointes with magnesium

Question 60

Vernakalant has

Answer 60

Class 3 and 1 b mechanism,so prolonged QT and QRS normal ,because of fastDK

Question 61

Vernakalant use

Answer 61

Acute Afib treatment

Question 62

Side effects of vernakalant

Answer 62

Hypotension and bradycardia

Question 63

Beta blockers and calcium channel blockers

Answer 63

Negative chronotropy dromotropy and inotropy

Question 64

Use of BAB

Answer 64

Frequency control of SVA and VA treatment

Question 65

Clinical use of Calcium channel blockers

Answer 65

Frequency control of SVA

Question 66

Magnesium sulphate

Answer 66

Reduces calcium flow in ventricular cardiomyocyte-Tdap treatment

Question 67

Atropine has

Answer 67

Positive chrono and dromotropy

Question 68

Atropine use

Answer 68

Sinus bradycardia and AV block

Question 69

Epinephrine has

Answer 69

Positive chrono,dromotropy and inotropy effect

Question 70

Epinephrine is used in

Answer 70

CPR

Question 71

Digoxin has

Answer 71

Positive inotropic effect,but negative dromotropy and chronotropy,so use to treat SVA

Question 72

Treatment of Digoxin toxicity

Answer 72

Potassium, magnesium aspartate,phenytoin against ventricular tachycardia and Digoxin immune Fab antibodies

Question 73

Class 1 a and 3 can cause

Answer 73

Prolonged QT interwal syndrome

Question 74

Prolonged QT interwal syndrome can be congenital or aquired

Answer 74

Medication affecting hERG (K channel for repolarization)