Antiarrhythmic Agents Flashcards

(47 cards)

1
Q

List the Class 1A: Na+ Channel Blockers

“Double Quarter Pounder”

A
  • Quinidine
  • Procainamide
  • Disopyramide

“Double Quarter Pounder”

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2
Q

List the Class 1B: Na+ Channel Blockers

“Mexican lettuce tacos”

A
  • Lidocaine
  • Tocainide
  • Mexiletine

“Mexican lettuce tacos”

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3
Q

List the Class 1C: Na+ Channel Blockers

“Purple motorola flip phone”

A
  • Flecainide
  • Propafenone
  • Moricizine

“Purple motorola flip phone”

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4
Q

Class 1A: Na+ Channel Blockers…

______ Vmax & ________ APD

A

↓ Vmax & Prolonged APD

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5
Q

Class 1B: Na+ Channel Blockers…

______ Vmax & ________ APD

A

NO EFFECT on Vmax & SHORTENED APD

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6
Q

Class 1C: Na+ Channel Blockers…

______ Vmax & ________ APD

A

Significantly ↓
Vmax & NO EFFECT
APD

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7
Q

What are the adverse effects of QUINIDINE? (4)

A
  1. Cinchonism
  2. ↑ QT interval (Torsades)
  3. Displaces digoxin from tissue binding sites
  4. Antacids will increase its absorption and toxicities
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8
Q

Which drug has the side effect of tinnitus, loss of hearing, GI upset, and diplopia?

A

QUINIDINE

Class 1: Na+ Channel Blocker

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9
Q

Which drug has the side effect with the use of antacids causing an ↑ in toxicities?

A

QUINIDINE

Class 1: Na+ Channel Blocker

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10
Q

Which drug has the side effect of *Agranulocytosis *

↓ WBC

A

PROCAINAMIDE

Class 1: Na+ Channel Blocker

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11
Q

Which drug has the side effect of SLE like syndrome?

A

PROCAINAMIDE

Class 1: Na+ Channel Blocker

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12
Q

What is the least anticholinergic Class 1: Na+ Channel Blocking Drug?

A

PROCAINAMIDE

Active metabolite NAPA (N-Acetyl procainamide)

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13
Q

What is the most anticholinergic Class 1: Na+ Channel Blocking Drug?

A

DISOPYRAMIDE

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14
Q

What two effects take place in the drug QUINIDINE?

A
  1. Anticholinergic Effect
  2. Alpha Blocking Effect
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15
Q

What is the action of the anticholinergic effect in the drug QUINIDINE?

A

Anticholinergic Effect: ↑ heart rate & conductance

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16
Q

What is the action of the alpha blocking effect in the drug QUINIDINE?

A

Alpha Blocking Effect: Vasodilation & Reflex Tachycardia

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17
Q

Which class of drugs increases the threshold for Vfib?

(more protective effect)

A

Class 1B: Na+ Channel Blocking Drug

  • Lidocaine
  • Mexiletine
  • Tocainide
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18
Q

Which Class 1B: Na+ Channel Blocking Drug is the least cardiotoxic?

A

LIDOCAINE

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19
Q

What are the adverse effects of LIDOCAINE? (3)

CLASS 1B: Na+ Channel Blocker

A
  • Drowsiness
  • Paresthesia
  • Convulsions
20
Q

Are the drugs MEXILETINE & TOCAINIDE given IV or orally?

CLASS 1B: Na+ Channel Blocker

A

ORALLY

LIDOCAINE is given IV

21
Q

Which class of drugs works on both the activated & inactivated Na+ channels?

A

Class 1C: Na+ Channel Blocking Drugs

  • Flecainide
  • Propafenone
  • Moricizine
22
Q

Which class of drugs are used for life threatening Vtach & Vfib?

Also used for Refractory SVT

A

Class 1C: Na+ Channel Blocking Drugs

  • Flecainide
  • Propafenone
  • Moricizine
23
Q

What are the adverse effects of Class 1C: Na+ Channel Blocking Drugs?

A
  1. Proarrhythimic Effect
  2. ↑ sudden death & cardiac arrest via decrease in LV function after an MI
24
Q

What is the drug of choice for SVT/PSVT in emergency situations?

25
What are the adverse side effects of adenosine? (3)
- Flushing - SOB - Burning sensation in the chest
26
Which drug has the following adverse side effects: flushing, shortness of breath, and burning in the chest?
ADENOSINE
27
What are the 2 clinical uses for DIGOXIN?
1. Heart Failure 2. Control ventricular rates in afib & aflutter
28
List the drugs that are capable of causing *Torsades de Pointes*. (5)
1. AMIODARONE 2. QUINIDINE 3. SOTALOL 4. THIORIDAZINE 5. TRICYCLIC ANTIDEPRESSANTS
29
List the Class II: Beta Blockers
- Meoprolol - Propranolol - Acebutolol - Esmolol
30
Which class of antiarrhythmics has the mechanism of action of ↓SA & AV nodal conduction? | Also has a decrease in the slope of phase 4 depolarization
Class II: Beta Blockers ## Footnote - Meoprolol - Propranolol - Acebutolol - Esmolol
31
What's the adverse effect of Class II: Beta Blockers? ## Footnote - Meoprolol - Propranolol - Acebutolol - Esmolol
Proarrhythmic: Can cause AV block | prolonged PR interval
32
Which Class II: Beta Blocker is given IV for emergency Rx of SVT? ## Footnote - Meoprolol - Propranolol - Acebutolol - Esmolol
ESMOLOL
33
What is the clinical use of Class II: Beta Blockers? (2) ## Footnote - Meoprolol - Propranolol - Acebutolol - Esmolol
1. Prophylaxis for ventricular arrhythmias Post MI 2. Rx of SVTs
34
Which class of drugs has the clinical use of : 1. Prophylaxis for ventricular arrhythmias Post MI 2. Rx of SVTs
Class II: Beta Blockers ## Footnote - Meoprolol - Propranolol - Acebutolol - Esmolol
35
Which class of drugs has the clinical use for Atrial Fibrillation & Ventricular Tachycardia?
Class 3: K+ Channel Blockers
36
List the Class 3: K+ Channel Blockers.
- Amiodarone - Sotalol - Dofetilide - Ibutilide - Dronaderone
37
Which class of drugs does the following: - ↑ APD & ERP - Prolongs repolarization and lengthen the PLATEAU phase (phase 2)?
Class 3: K+ Channel Blockers. ## Footnote - Amiodarone - Sotalol - Dofetilide - Ibutilide - Dronaderone
38
What are the adverse effects of AMIODARONE?
- Pulmonary Fibrosis - Hepatotoxicity - Smurf Skin - Hypothyroidism & Hypethyroidism - Torsades de Pointes
39
Which drug has the adverse effects of pulmonary fibrosis and hepatotoxicity?
AMIODARONE
40
Which Class 3: K+ Channel Blocker drugs are used for pharmacological cardioversion of atrial fibrillation and flutter?
IBUTILIDE & DOFETILIDE
41
Which drug's clinical use pertains to atrial fibrillation and life-threatening ventricular arrythmias?
SOTALOL
42
Which drug has the following side effects: - Torsades de Pointes - Headaches, depression, and impotency - Issue with asthmatics
SOTALOL ## Footnote Class 3: K+ Channel Blockers
43
List the Class 4: Calcium Channel Blockers
- DILITIAZEM - VERAPAMIL
44
Which class of drugs have the clinical use of PSVT due to AV nodal re-entry?
Class 4: Calcium Channel Blockers ## Footnote - DILITIAZEM - VERAPAMIL
45
Which class of drugs contain the adverse effects of orthostatic hypotension and lower extremity edema?
Class 4: Calcium Channel Blockers ## Footnote - DILITIAZEM - VERAPAMIL
46
Which Class 4: Calcium Channel Blocker displaces digoxin and increases its toxicity as a result?
VERAPAMIL
47
Which class of drugs has the adverse effect of atrial tachycardia due to WPW? ## Footnote delta wave
Class 4: Calcium Channel Blockers ## Footnote - DILITIAZEM - VERAPAMIL