Antiarrhythmic Therapies

Question 1

Quinidine (Quinidex)

Class, MOI, Use, SE, Contraindications

Answer 1

Class: 1A
Mechanism of Action:
Use: Available orally. Atrial, AV junctional, and ventricular tachyarrhythmias to convert back to normal sinus or as maintence to prevent arrhythmia.
Side Effects: Blurry vision, tinnitus, headache, psychosis
Contraindications:

Question 2

Procainamide (Pronestyl)

Class, MOI, Use, SE, Contraindications

Answer 2

Class: 1A
Mechanism of Action:
Use: IV only, treats acute atrial or ventricular arrhythmias. (not commonly used).
Side Effects: Hypotension
Contraindications:

Class, MOI, Use, SE, Contraindications

Question 3

Lidocaine (Xylocaine)

Answer 3

Class: 1B
Mechanism of Action:
Use: IV only, can terminate V-Fib and V-Tach, and prevent V-Fib after cardioversion in setting of acute ischemia.
Side Effects: CNS changes (nystagmus, slurred speech, drowsiness)
Contraindications: Routine use may increase mortality by increasing insidence of asystole.

Question 4

Mexiletine (Mexitil)

Class, MOI, Use, SE, Contraindications

Answer 4

Class: 1B
Mechanism of Action:
Use: Chronic preventative treatment of ventricular arrhythmias.
Side Effects: Narrow theraputic index
Contraindications:

Question 5

Flecainide (Tambocor)

Class, MOI, Use, SE, Contraindications

Answer 5

Class: 1C
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 6

Propafenone (Rythmol)

Class, MOI, Use, SE, Contraindications

Answer 6

Class: 1C
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 7

Esmolol (Brevibloc)

Class, MOI, Use, SE, Contraindications

Answer 7

Class: B-adrenoceptor Antagonist (class II)
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 8

Metroprolol (Lopressor)

Class, MOI, Use, SE, Contraindications

Answer 8

Class: B-adrenoceptor Antagonist, cardioselective (class II)
Mechanism of Action: Diminishes phase 4 depol to prolong action potential.
Use: Oral or IV, Most widely used in treatment of cardiac arrhythmias.
Side Effects:
Contraindications:

Question 9

Propanolol

Class, MOI, Use, SE, Contraindications

Answer 9

Class: B-adrenoceptor Antagonist (class II)
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 10

Amiodarone (Cordarone)

Class, MOI, Use, SE, Contraindications

Answer 10

Class: 3, AP prolongation
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 11

Dronedarone (Multaq)

Class, MOI, Use, SE, Contraindications

Answer 11

Class: 3, AP prolongation
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 12

Sotalol (Betapace)

Class, MOI, Use, SE, Contraindications

Answer 12

Class: 3, AP prolongation
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 13

Dofetilide (Tikosyn)

Class, MOI, Use, SE, Contraindications

Answer 13

Class: 3, AP prolongation
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 14

Diltiazem (Cardizem)

Class, MOI, Use, SE, Contraindications

Answer 14

Class: 4, Non-DHP calcium channel blocker
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 15

Verapamil (Isoptin, Calan)

Class, MOI, Use, SE, Contraindications

Answer 15

Class: 4, Non-DHP calcium channel blocker
Mechanism of Action: Slows phase four spontaneous depol and slows conduction in tissues dependent on calcium currents
Use: Terminates supraventricular tachycardia (IV form), Rate control in afib and flutter (IV and oral)
Side Effects:
Contraindications:

Question 16

Adenosine

Class, MOI, Use, SE, Contraindications

Answer 16

Class:
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 17

Atropine

Class, MOI, Use, SE, Contraindications

Answer 17

Class:
Mechanism of Action:
Use:
Side Effects:
Contraindications:

Question 18

Dobutamine

Class, MOI, Use, SE, Contraindications

Answer 18

Class:
Mechanism of Action:
Use:
Side Effects:
Contraindications: