Antibacteria Flashcards Preview

Pharm II > Antibacteria > Flashcards

Flashcards in Antibacteria Deck (52):
1

Cephalosporins drugs

CEfazolin
CEftriaxone
CEphalexin

2

Examples:
ImipENEM
meropENEM

Carbapenems

3

Examples:
Amoxicillin
Penicillin V potassium

Penicillins

4

Side effects and adverse effects of antibiotics

S/e: GI- diarrhea, vomiting; yeast effects
A/e: allergic rxn, anaphylaxis , C. Diff

5

Cell synthesis inhibitors-

Penicillins
Carbapenems
Cephalosporins
Other- vancomycin

6

Side effects of penicillins & cephalosporins

Diarrhea
Itchiness

7

Side effects: irritation at IV site

Carbapenems & Vancomycin

8

Adverse effect of Penicillin

General antibiotics adverse effects: allergic rxn, anaphylaxis, C. Diff

9

Adverse effect: nephrotoxicity

Cephalosporins

10

Carbapenems adverse effects

Nephrotoxicity
Ototoxicity
Seizures

11

Adverse effects:
Nephrotoxicity
Ototoxicity
Red Man Syndrome

Vancomycin

12

What is Red Man Syndrome

Body is producing histamine release leads to a drop in BP. This leads to red color in the patient.
To prevent RMS: slow down rate of infusion
Give anti-histamine

13

Cephalosporins: check before

Give 1 hour before or 4 hours after iron or antiacid
Check kidney function (BUN, Creatine, urine output)

14

Check before: Carbapenems

Check for previous seizures

15

Check before: vancomycin

Give slowly

16

Cell wall synthesis inhibitors: check after

Oral dose: check hourly for 4 hours after 1st dose

IV dose: check every 15-30 mins for 2 hours after 1st dose

17

Aminoglycosides (can be IV or IM)

TAG
Tobramycin
Amikacin
Gentamicin

18

Marolides

ACE
Azithromycin
Clarithromycin
Erythromycin

19

Tetracyclines

DT
Doxycycline
Tetracycline

20

Protein systems is inhibitors

Aminoglycosides
Macrolides
Tetracycline
Clindamycin
Linezolid

21

S/e of aminoglycosides

N/V, diarrhea, rash, fever, malaise, lethargy

22

S/e:
N/V, diarrhea, photosensitivity

Macrolides

23

S/e:
N/V, diarrhea, sore tongue, photosensitivity

Tetracyclines

24

Lindzolid s/e

Increase BP with a person that has high BP

25

Adverse effects:
Ototoxicity, nephrotoxicity, neuromuscular blockade (muscle weakness, respiratory depression)

Aminoglycosides

26

Macrolides

Serious drug interactions (digoxin & Coumadin); notorious for failed birth control

27

Tetracycline A/E

Increased ICP

28

Clindamycin A/E

Decreased WBCs, reduced liver function

29

Linezolid
A/E

Reduces RBCs & platelets, damage to optic nerve

30

Before giving aminoglycosides

Assess breathing baseline
BUN & creatinine, hearing, muscle strength

31

Before giving Macrolides

Check danger with other drugs, give IV erythromycin within 8 hours of
Dilution

32

Check before giving tetracyclines

Food, antacids, diary products decrease absorption
Therefore better on empty stomach

33

After administration of Linezolid

Check BP

34

Check after giving Macrolides

HR & rhythm q 4hours & prn

35

Tetracycline: check after giving

Drug interactions with Coumadin

36

Check after giving Aminoglycosides

Hearing, temperature, I&O, lab values (BUN & creatinine)

37

Teaching of Macrolides

Take with food to decrease GI side effects
Avoid sun exposure
Erythromycin reduces effect of BC pills

38

Tetracycline teachings

Take 1 hour before or 2 hours after meals; don't take with milk

Increase fluid intake

39

Linezolid teaching

Avoid taking with food containing tyramine

40

Metabolism inhibitors

Sulfonamides: sulfadiazine sodium & trimethoprim

Combo drugs: trimethoprim/ sulfamethoxazole

41

Side effects of metabolism inhibitors

Headache, fever, rash, photosensitivity

42

Adverse effects of metabolism inhibitors

Kidney stones (sulfonamide )
Suppression of bone marrow
Steven-Johnson syndrome
Hepatitis (noninfectious)

43

Check before: metabolism inhibitors

Sulfa allergies
Lab tests: G6pd deficiency affects RBCs and when med Is given, it will cause RBC hemolysis

44

Check after: metabolism inhibitors

Jaundice, bruises, petechia, blisters, Increase fluids to prevent stones

45

Fluoroquinolones

Ciprofloxacin
Levofloxacin

46

Ciprofloxacin

Treats many infections
Don't treat staph it gonorrhea anymore

47

Concentrate in urine- increase fluid intake
Increase risk for C diff

Dna synthesis inhibitors
Fluoroquinolones - Ciprofloxacin and Levofloxacin

48

Rash, nausea, abdominal pain, pain
Headache

Fluoroquinolones

49

Adverse effects of dna synthesis

Serious heart dysrhythmias
Neurotoxicity
Peripheral neuropathy
Steven-Johnson syndrome
Changes in blood glucose levels (if pt is DM)
Tendon rupture

50

Fluoroquinolones check before

Pt also taking iron, vitamin, antiacids

Antidysrhythmic drug therapy

51

Check after

Heart rate and rhythm q4h

52

Patient teaching Fluoroquinolones

Take with full glass of water, increase fluid throughout the day
Check pulse twice daily
If diabetic, check blood glucose more often
Stop drug and notify prescriber of any tendon or joint pain/swelling