Antibacterial Agents 4: Inhibitors of DNA Function Flashcards Preview

DnD Unit 4 > Antibacterial Agents 4: Inhibitors of DNA Function > Flashcards

Flashcards in Antibacterial Agents 4: Inhibitors of DNA Function Deck (15):
1

In General, DNA inhibiting drugs are (Bactericidal or bacteriostatic)?

Bactericidal.

Can you name the other classes and their action?

2

What are the 3 durgs in the Fluoroquinolone class? Yes this IS important to know.

**1. Ciproflaxin
**2. Levofloxacin
3. Moxifloxacin

** "most important for exam"

3

What are each of the 3 Fluoroquinolone effective in treating?

1. Cipro (U)
2. Levo (UR)
3. Moxi (R)

U=Urinary
R= Respiratory (gram + cocci)

*Put drugs in alphabetical order and then start with "U" and go all the way to "R"

4

In general, dugs inhibiting intermediary metabolism are (Bactericidal or bacteriostatic)?

Bacteriostatic

-Cidals
Membrane
Cell Wall
DNA

-Statics
Metabolism
Protein synthesis

5

What is the primary mechanism of resistance for Fluoroquinolones?

Alter drug target.

6

Fluoroquinolones are generally administered via which route?

Oral

(Cipro and levo can also be parenteral)

7

Which bacterias usually cause Respiratory infections?
Which Flouro would you use to treat?

Staph Pneumoniaes
Staph Pyogenes

Use Levo

8

Which bacterias usually cause urinary infections?Which Flouro would you use to treat?

Pseudomonas
E. Coli

Use Cipro

9

Why doesn't Moxiflocacin treat UTIs?

It doesn't concentrate in urine.

10

What are the major contraindications and adverse reactions for Fluoroquinolone usage?

1.Children under 12 2. Pregnancy
Due to potential arthopathies.

Avoid Caffene

11

What is nitrofurantoin primarily used for?

UTIs

It is a urinary tract antiseptic

12

Consuming alcohol with this drug leads to nausea, vomiting, cramps, flushing and headache.

Metronidazole

13

Using a sulfonamide in neonate populations can cause

Kernicterus- bilirubin induced brain dysfunction

14

True or false:
Dihydrofolate Reductase is found only in bacteria.

False

It is found in humans and bacteria.

15

To make a sulfonamide bactericidal, it must be administered with _________

Trimethoprim