Antibacterial Agents-Inhibit Protein Synth

Question 1

Aminoglycosides

Answer 1

(streptomycin) Bind irreversibly to 30S and cause premature release [must be aerobic environ] [streptococci/enterococci resist due to cell wall]
- ->GNR Enterobacteriaceae, Pseudomonas, Acinetobacter

Question 2

RESISTANCE- Aminoglycosides

Answer 2

1. mutated ribosomal binding site
2. decrease uptake into cell
3. increased expulsion from cell
4. enzymatic modification of the antibiotic

Question 3

Tetracyclines

Answer 3

broad spectrum- bind reversibly to 30s preventing elongation

–> Chlamydia, Mycoplasm, Rickettsia

Question 4

Glycylcycline

Answer 4

binds to 30s preventing initiation

Question 5

Oxazolidinones

Answer 5

narrow spectrum-blocks initiation of protein synthesis by binding 50S
[reserved for multi-drug resistant enterococci]

Question 6

Macrolides

Answer 6

reversibly bind 50S blocking elongation

Question 7

Ketolide

Answer 7

reversibly bind 50S blocking elongation

Question 8

Clindamycin

Answer 8

reversibly bind 50S blocking elongation

Question 9

Streptogramins

Answer 9

reversibly bind 50S blocking elongation– used for vancomycin resistant E. faecium