antibacterial drugs targeting the cell envelope

Question 1

what does trans glycosylation and transpeptidation involve

Answer 1

they are part of peptidoglycan synthesis 1st one is polymerisation of glycan strands the second one is cross linking between glycan strands.

Question 2

what catalyses both reactions in the synthesis

Answer 2

penicillin binding proteins which are bi functional with 2 separate domains and they are membrane associated.

Question 3

what are the two types of antibiotic classes that interfere with these final stages

Answer 3

beta-lactams, glycopeptides

Question 4

how does beta lactam work

Answer 4

affects transpeptidation by blocking cross linking of peptide side chains

Question 5

what do peptidoglycan hydrolases do

Answer 5

cleave PG during normal growth and they are not inhibited by beta lactams so they continue to hydrolyse and lead to a weak PG

Question 6

what are some side affects of beta lactams

Answer 6

hypersensitivity, anaphylactic shoch after injection.