antibiotic

Question 1

what is the mode of action of glycopeptides

Answer 1

inhibit cell wall synthesis
bind with high affinity to terminal 2D alanine residues at carboxyl end of peptapeptide
sterically hinder the elongation of peptidoglycan

Question 2

what is the spectrum of glycopeptides

Answer 2

positive (high Mw cant peneterate -ve) 
staph aureus MRSA 
streptococci 
s.pneumonia 
s.pyogenes 
.s.viridians 
cornyebacter 
clostidium 
enterococci 
-ve bacilli

Question 3

what is the indication of vancomycin and teicoplanin

Answer 3

osteomylis
endocarditis ( mrsa and stphylococci)
px for endocarditis before operation witrh patient with Pc allergy

Question 4

explain pk of glycopeptides

Answer 4

van poor A 
teic IV not IM 
not metabolised 
wide into csf aswell 
teico high plasma protein binding

Question 5

what is the mode of action of macrolides

Answer 5

bind reversibly to 23S rRNA
inhibit translocation so that the growing peptide chain at the A site fails to move to P site preventing the release of tRNA after peptide bond formation

Question 6

what is the spectrum of macrolides

Answer 6

\+ve and -ve 
streptococci 
clostidium perifegins 
excellent with; 
chlymadia spp 
L.pneoumophillia 
m. pneumonia 
moraxella cattarhalis

Question 7

explain pk of macrolids

Answer 7

acid sensitive not with food 
absorption similar between oral and iv 
not in brain and CSF 
liver elimination 
CYP3A$ 
10-15 percent unchanged in urine