Antibiotic Coverage

Question 1

Gram Positive

Answer 1

Strep pneumoniae (=Pneumococcus)
Strep group A beta hemolyticus (= Strep pyogenes)
Staph aureus (MSSA, MSRA)

Question 2

Atypical bacteria

Answer 2

Mycoplasma 
Chlamydia pneumoniae (C. pneumoniae)

Question 3

Gram Negative

Answer 3

Hemophylus influenza (H.flu)
Pseudomonas 
E.coli
Proteus
Klebsiella

Question 4

Strep group A beta hemolyticus (streptococcus pyogenes)

Answer 4

Conditions: Pharyngitis (strep throat)

Comments:Strep group A may cause skin infections, rheumatic fever and post-streptococcal glomerulonephritis

Question 5

Strep pneumoniae (pneumococcus)
H. Influenzae

Answer 5

Conditions: Otitis media, sinusitis

Comments: Strep Pneumoniae can cause pneumonia and meningitis

Question 6

Strep pneumoniae
H.influenzae

      AND 

Atypical:

• Mycoplasma
• Chlamydia pneumoniae

Answer 6

Lungs: Pneumonia

Question 7

Strep. spp (group A, B)
Staph spp ( MSSA, MRSA)

Answer 7

skin conditions: 
Skin infections 
Osteomyelitis 
Septic joint 
Endocarditis 
Otitis externa 
Conjunctivitis

Question 8

E.coli
Proteus
Klebsiella

Answer 8

Colon: always gram negative 
Cystitis
Pyelonephritis 
Prostatitis  
Diverticulitis 
Cholecystitis 
Cholangitis

Question 9

PCN/ Amoxicillin

Answer 9

PCN – Strep pyogenes.
Amox- Strep, sensitive strains E. Coli , Proteus, H.flu

no coverage: Do not cover Staph spp, atypical

Question 10

Amoxicillin w/ clavulanate

Answer 10

Gram+ (only Strep) , Gram– (H.flu, Moraxella)

No coverage: Do not cover Pseudomonas, Staph, atypical

Question 11

Cephalosporins

Answer 11

Gram+(Strep and Staph). 2nd and 3rd gen more eff against Gram -

Do not cover MRSA, Pseudomonas, atypical

Question 12

Macrolides

Answer 12

Broad coverage (Gr+, Gr-, atypical)
Do not cover Pseudomonas, MRSA

Question 13

Respiratory FQ (levofloxacin, moxifloxacin)

Answer 13

Broad coverage (Gr+, Gr-, atypical)
Do not cover Pseudomonas, MRSA , anaerobes

Question 14

Non-respiratory FQ (cipro-)

Answer 14

Mostly Gram - ; Covers Pseudomonas

Less effective against Gr+, anaerobes. Not effective against MRSA

Question 15

Clindamycin

Answer 15

Only Gr+ (Strep and Staph). Covers MRSA

No coverage against gram neg

Question 16

Doxycycline

Answer 16

Broad coverage (Gr+, Gr-, atypical). Covers MRSA

Unreliable coverage against Gr – and Strep

Question 17

TM)P-SMX (bactrim)

Answer 17

Gr+ (including MRSA), Gr-. Covers MRSA

Unreliable coverage against Gr – and Strep

Question 18

Strep group A beta hemolyticus (= streptococcus pyogenes)

Answer 18

Conditions: Strep Throat (Pharyngitis)
#1 antibiotic: Pen VK
Optional: Macrolides , Cephalosporins (1st gen, < 5% cross-reactivity w/ PCN), Clindamycin

Question 19

Strep pneumoniae

H.flu

Answer 19

Conditions: Otitis media , Sinusitis
Antibiotics: Amoxi can be given for otitis
Amoxi+ Clav for sinusitis

Optional: Macrolides , Cephalosporins (< 5% cross-reactivity w/ PCN)
Clindamycin , Respiratory FQ

Question 20

Strep pneumoniae

H.influenzae

Atypical :

• Mycoplasma
• Chlamydia pneumoniae
• Legionella

Answer 20

Conditions: Pneumonia
Antibiotics: Macrolids, Respiratory FQ

Optional : Beta-lactam ( 2nd or 3rd gen) + doxycycline