Antibiotics 1

Question 1

V (oral), G (IV), Benzathine (IM, longer lasting)

Answer 1

Penicillin

Question 2

Binds penicillin binding protein – inhibits transpeptidase

Answer 2

Penicillin

Question 3

Nafcillin, Dicloxacillin, Antistaph penicillins

Answer 3

Penicillinase-resistant penicillins

Question 4

Same as penicillin, larger R group so resistant to penicillinase

Answer 4

Penicillinase-resistant penicillins

Question 5

Clavulanate (penicillin), Sulbactam, Tazobactam

Answer 5

Beta-lactamase inhibitors

Question 6

Binds irreversibly to beta-lactamase

Answer 6

Beta-lactamase inhibitors

Question 7

Ampicillin, Amoxicillin

Answer 7

Amino-penicillins

Question 8

Water soluble and can pass through porins – same mechanism as penicillin

Answer 8

Amino-penicillins

Question 9

Ticarcillin, piperacillin

Answer 9

Anti-pseudomonal penicillin

Question 10

Same as penicillin, usually only used to treat pseudomonas

Answer 10

Anti-pseudomonal penicillin

Question 11

Monobactum

Answer 11

Axtreonam

Question 12

Monocyclic beta-lactam, same mechanism as penicillin

Answer 12

Axtreonam

Question 13

Excreted by kidney (watch for renal insufficiency)

Answer 13

Cephalo-sporins

Question 14

Same mechanism as penicillin, bacteriocidal beta-lactams

Answer 14

Cephalo-sporins

Question 15

Cephalexin

Answer 15

Ceph 1st Gen

Question 16

Surgical Prophylaxis

Answer 16

Ceph 1st Gen

Question 17

Cefoxitin,

Answer 17

Ceph 2nd Gen

Question 18

Used immediately prior to surgery

Answer 18

Ceph 2nd Gen

Question 19

Ceftriaxone, cefotaxime,
Ceftazidime,
cefdinier

Answer 19

Ceph 3rd Gen

Question 20

Cefepime

Answer 20

Ceph 4th Gen

Question 21

Ceftaroline

Answer 21

Ceph 5th Gen

Question 22

Binds to PBP 2a present in MRSA

Answer 22

Ceph 5th Gen

Question 23

Imipenem/

cilastatin meropenem

Answer 23

Carbapenems

Question 24

Beta-lactam ring, binds PBP, parenteral admin

Answer 24

Carbapenems

Question 25

Bacteriocidal, oral vanco is poorly absorbed

Answer 25

Vancomycin

Question 26

Binds to DADA terminus of cell wall precursor unit, inhibits transglycosylase rxn

Answer 26

Vancomycin

Question 27

Poor bioavailability, topical ophthalmic and derm preps

Answer 27

Bacitracin

Question 28

Prevents dephosphorylation of bactoprenol carrier (needed for elongation of PG cell wall)

Answer 28

Bacitracin

Question 29

Bind to LPS, creates holes in outer membrane | bacteriocidal

Answer 29

Polymyxin B

Question 30

Binds to cell membrane and aggregates, depolarizes cell

Answer 30

Daptomycin