Antibiotics

Question 1

Community acquired sepsis with no known cause

Answer 1

Cefuroxime 1.5g IV q8h
If intraadominal source add Metronidazole 500mg IV q12h

Question 2

Hospital acquired sepsis with no known cause

Answer 2

Cefuroxime 1.5g IV q8h (no hypotension or organ dysfunction)

Piperacillin + Tazobactam 4.5g IV q6h (severe sepsis - organ dysfunction)

Question 3

Meningitis

Answer 3

Dexamethaxone 10mg IV q6h (4/7) + Ceftriaxone 2g IV q12h + Vancomycin 1.5g IV q12h

Question 4

Community acquired pneumonia

Answer 4

CURB 0: Amoxicillin 1g PO q8h

CURB 1-2: Amoxicillin 1g PO q8h + Azithromycin 500mg PO q24h

CURB 3-5: Ceftriaxone IV 2g q24h + Azithromycin PO 500mg q24h

Question 5

Hospital acquired pneumonia

Answer 5

Piperacillin +Tazobactam IV 4.5g q6h

Question 6

Acute peritonitis/appendicitis/cholangitis/cholecystitis/diverticulitis

Answer 6

Cefuroxime 1.5g IV q8h + Metronidazole 500mg IV q12h
OR
Amoxicillin clavulanate 1.2g IV q8h

Question 7

UTI

Answer 7

Uncomplicated: Trimethoprim PO 300mg q24h OR Nitrofurantoin 50mg PO q6h

Community acquired pyelonephritis: cefuroxime 1.5g IV q8h OR gentamicin 5mg/kg IV q24h (if <60) OR ertapenem IV 1g q24h (high risk, multi-drug resistant)

Question 8

Cellulitis

Answer 8

Flucloxacillin 1g PO q8h

Question 9

Necrotising Fasciitis

Answer 9

Limbs: Flucloxacillin IV 2g q6h +Clindamycin IV 600mg q6h

Abdo/groin:
pipercillin + tazobactam 4.5g IV q6h + Clindamycin IV 600mg q6h

Question 10

Diabetic foot infection

Answer 10

Mild:
Amoxicillin clavulanate PO 625mg q8h

Severe:

Amoxicillin clavulanate IV 1.2g q6h