Antibiotics

Question 1

Name the antibiotics which function by inhibiting bacterial cell wall synthesis?

Answer 1

Penicillins

Cephalosporins

Imipenem

Meropenem

Aztreonam

Vancomycin

Teicoplanin

Bacitracin

Question 2

Name some antibiotics which function by inhibiting the ATPase activity of DNA Gyrase?

Answer 2

Quinolones:
Nalidixic acid

Ciprofloxacin

Novobiocin

Question 3

Name some antibiotics which function by inhibiting bacterial DNA directed RNA polymerase (RNAP) ?

Answer 3

Rifampin

Streptovaricins

Question 4

Name some antibiotics which function by inhibiting the 50S ribosomal subunit of bacteria (essentially inhibiting protein synthesis) ?

Answer 4

Macrolides (Erythromycin, Clarithromycin & Azithomycin)

Chloramphenicol

Clindamycin

Lincomycin

Question 5

Name some antibiotics which function by inhibiting the 30S ribosomal subunit of bacteria (essentially inhibiting protein synthesis) ?

Answer 5

Tetracyclines

Spectinomycin

Streptomycin

Gentamicin

Kanamycin

Amikacin

Nitrofurans

Question 6

Name some antibiotics which function by inhibiting tRNA (transfer RNA) (essentially inhibiting protein synthesis) ?

Answer 6

Mupirocin

Puromycin

Question 7

Name some antibiotics which function by disrupting the structure of the cytoplasmic membrane of bacterial cells?

Answer 7

Polymyxins

Daptomycin

Question 8

Which antibiotic acts by inhibiting folic acid synthesis within bacterial cells by inhibiting the enzyme dihydrofolate reductase?

Answer 8

Trimethoprim

Question 9

Which antibiotics act by inhibiting folic acid synthesis within bacterial cells by blocking the incorporation of para-amino-benzoic acid (PABA) into the folic acid pathway?

Answer 9

Sulfonamides (Sulfamethoxazole, sulfamethazine etc)

Question 10

Name the three oral antibiotics available for use by podiatrists with the POM-S annotation

Answer 10

Flucloxacillin

Amoxicillin

Erythromycin

Question 11

What topical antibiotic is available for podiatric use under the POM-S annotation?

Answer 11

Silver Sulfadiazine (Flamazine cream)

Question 12

What enzyme involved in folate synthesis is competitively inhibited by sulfonamide antibiotics?

Answer 12

Dihydroteroate Synthase - An enzyme vital in the conversion of P-aminobenzoic acid (PABA) into dihydroteroate, which then is synthesised into dihydrofolate, which is then converted into tetrahydrofolate, which is an essential building block of bacterial DNA

Question 13

What enzyme involved in bacterial DNA synthesis is competitively inhibited by Trimethroprim?

Answer 13

Dihydrofolate Reductase - An enzyme that is essential for the conversion of dihydofolate into tetrahyrofolate, a vital building block of bacterial DNA