antibiotics Flashcards

(75 cards)

1
Q

SATA

Why not just prescribe a “really strong” antibiotic?
a) Will delay effective treatment
b) Will give the bacteria more time to grow.
c) Can contribute to the development of drug-resistant bacteria
d) Could result in a lawsuit
e) Could result in an allergic response.

A

a) Will delay effective treatment
b) Will give the bacteria more time to grow.
c) Can contribute to the development of drug-resistant bacteria

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2
Q

Bactericidal

A

—kill bacteria

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3
Q

Bacteriostatic

A

—slow growth of bacteria

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4
Q

What is the mechanism of action for ABX treatment?

A

Affect target organism’s structure, metabolism, or life cycle

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5
Q

What is the main goal of ABX treatment

A

Goal is to eliminate pathogen

by either bactericidal or bacteriostatic properties

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6
Q

When would ABX treatment be used prophylactically

A

May be used for prophylactic treatment of people with suppressed or compromised immune systems

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7
Q

What is chemoprophylaxis

A

the administration of a medication for the purpose of preventing disease or infection.

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8
Q

Close contacts and family members of recently infected tuberculosis clients should?

A

begin therapy immediately after a client has a positive tuberculin
test.

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9
Q

What 11 things should the nurse provide education on when their patient is recieving ABX treatment.

A
  1. Make sure pt knows to finish all abx
  2. Do not share
  3. Keep away from children (safety lid and lock)
  4. Educate that abx decreases oral contraception and use back up birth control.
  5. Teach when to take with food or when to avoid certain foods (ie Ca/Iron – Tetras)
  6. Teach clients to wear medic-alert bracelets if allergic
  7. Inform as to SE (skin, teeth, tendons, ears, kidneys)
  8. Tell pts to take probiotics (1-2x/day) to counter antibiotic
  9. Monitor for hypersensitivity with first dose
  10. Make sure pt know S&S of allergic rxn
  11. MOST antibiotics are best taken on empty stomach
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10
Q

Location will affect how long abx treatment is, what two areas will result in longer treatment?

A

people with sinus infections or bone infections will be on antibiotic longer.

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11
Q

Why should patients be discouraged from sharing antibiotics?

What will this do to the infection

A

-sharing abx can change infection presentation.

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12
Q

What is a common side effect of ALL antibiotics?

A

Nausea, vomiting, diarrhea

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13
Q

Replacement of natural colon flora with a)… or b)…
may help to alleviate symptoms when taking antibiotics.

A

a) Probiotic supplements
b) Cultured dairy products such as yogurt or
buttermilk

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14
Q

After parenteral administration of abx, the nurse should observe the patient for a)… in case of allergic reactions

especically after first dose

A

for 30 minutes

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15
Q

a) Especially in elderly, the nurse should assess the function of what two organs?
b) a gain of (blank) may indicate the failure of these two organs.

A

a) renal and hepatic function.
b) 2.2lb or 1kg/day

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16
Q

What should the nurse assess for in children who are recieving abx treatment?

A

persistent diarrhea

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17
Q

What class of antibiotics should ALSO be avoided if a patient has a penicillin allergy

A

cephalosporins

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18
Q

In order to avoid allergic reaction to penicillin, the nurse should assess what in regards to the food the patient eats?

A

Assess animal products exposed to abx

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19
Q

What electrolytes should the nurse monitor in patients who are taking penicillin?
Will these electroylytes by high or low?

A

Monitor for hyperkalemia and hypernatremia

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20
Q

What patients are at a increased risk for hyperkalemia and hypernatremia when taking penicillins?

A

patients with DM, and who are on dialysis

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21
Q

When a patient is taking penicillin, what should the nurse be careful to monitor?

A

Monitor cardiac status, including ECG changes

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22
Q

When recieving cephalosporin abx treatment, the nurse should consider what 4 things?

A

1) Assess for presence or history of bleeding disorders (may reduce prothrombin levels)
2) Assess renal and hepatic function (esp. in elderly)
3) Assess for persistent diarrhea in children
4) Avoid alcohol

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23
Q

When combined with alcohol, some cephalosporings can cause what?

A

disulfiram (Antabuse)–like reaction,

severe vomiting

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24
Q

What should patients taking oral contraceptives be educated on while also taking Tetracyclines?

A

Tetracyclines decrease effectiveness of oral contraceptives

Alternate birth-control method should be used while taking medication

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25
Female patients taking tetracyclines have a increased potential to get a)... while taking oral contraception and Tetracyclines together.
vaginal yeast infection
26
Tetracyclines should be used cautiously in patients with
with impaired kidney or liver function
27
Should Tetracyclines be taken, a) with meals b) without meals c) without regard to meals
Tetracyclines should be taken **b) without meals** The abx should be taken on a empty stomach as this increases absorption!
28
Patients travelling to hot climates should be cautioned that Tetracyclines can cause what?
Photosensitivity reactions
29
Tetracyclines should NOT be taken with what 4 things?
1) milk products 2) iron supplements 3) magnesium-containing laxatives, 4) antacids (fluoros)
30
What infection should be watched for in patients who are taking Tetracyclines?
Watch for supra infection such as pseudomembranous colitis.
31
what abx is a safe alternatives to penicillin
Macrolides
32
Macrolides cause what taste in the mouth?
a metallic taste
33
Macrolides have the potential to exacerbate what disease?
exacerbates heart disease
34
Why do mutiple drug to drug reactions occur with Macrolides?
Macrolides are on the CYP pathway
35
When taking (EES) erythromycin, what should the nurse be cautious to monitor? (Macrolide)
The liver
36
When taking Macrolides, what type of infection should the nurse monitor for?
Respiratory infections
37
What class of abx is reserved for serious systemic infections
AMINOGLYCOSIDES
38
What are the three potential adverse reactions with Aminoglycosides?
1. Ototoxicity (worse if given with Lasix (furosemide)) 2. Nephrotoxicity (worse if given with Zovirax (acyclovir)) 3. Neuromuscular blockage (including respiratory paralysis)
39
What should be taken when on Aminoglycoside tmt to prevent toxicity?
Peak and troughs. Troughs before admin and peaks when drug should be at its highest
40
What abx is easy to start taking at home and why?
Fluoroquinolones because, IV dose = PO dose ***Therefore easy transition to home
41
What populations of people should not take Fluoroquinolones and why?
No teenagers or athletes, or elderly taking corticosteriods!!! - Tendon Rupture
42
What should a patient be advised to NOT take if on Fluroquinolone treatment and why?
Multivitamins or minerals such as calcium, magnesium, iron, or zinc ions as this causes 90% less absorption. (Tetras decreased by 50%)
43
Fluroquinolone can cause **serious** adverse reactions such as
dysrhythmias and liver failure, and CNS disturbances F= for flutter
44
What possible adverse reaction when taking Fluroquinolones can be seen on a ECG
QT Prolongation/Arrhythmias
45
what infection can be caused by Fluroquinolones use
C-diff
46
why should patients who are breast feeding NOT take fluroquinolones
Crosses into breast milk
47
# Fluroquinolones drug What is a adverse reaction seen in Norfloxacin?
Norfloxacin (black sheep drug in fluroquinolones family) may cause photophobia: lights bother eyes.
48
49
Widespread use of a).... has led to increased resistance and decreased usage
Sulfonamides
50
What category pregnancy rating are sulfonamides?
Teratogenic **X** (birth defects)
51
Other than treating infection, what other use do Sulfonamides have?
Anti-inflammatory properties of sulfonamide component can help with RA and ulcerative colitis
52
Sulfonamides are often used in combination to treat what type of infection?
UTI
53
Sulfonamide adverse reactions (6)
skin rashes, nausea, vomiting, agranulocytosis or thrombocytopenia (use cautiously with pernicious anemia), photosensitivity.
54
Mechanism of action for Sulfonamides?
to kill bacteria by inhibiting bacterial metabolism of folic acid
55
What are the four primary uses of Sulfonamides
urinary tract infections, Pneumocystis carinii pneumonia, shigella, and bronchitis | : Are broad spectrum
56
# CAUTION Reaction to sulfonamides could indicate allergic reaction to other sulfonamide medications such as? (4 drug classes)
1. **DM sulfonylureas**— i.e. glyburide (Glynase, Diabeta) and glimepiride (Amaryl) 2. **NSAIDs** – i.e. celecoxib (Celebrex) 3. Certain "water pills" **(diuretics)** – i.e. furosemide (Lasix) and chlorothiazide (Microzide) 4. **IBD** - sulfasalazine (Azulfidine)
57
in regards to the blood, what should the nurse assess for in patients who are taking sulfonamides
Assess for anemia or other hematological disorders (HgB & platelets)
58
# think kidney sulfonamides may increase risk for?
crystalluria | increase fluid intake
59
Patients taking OCP while on sulfonamide treatment should?
Use alternative contraception
60
What serious hypersensitvity reaction do sulfonamides put patients at?
Steven-johnsons syndrome (SJS)
61
Patients who are traveling to a hot climate should be cautious when taking sulfonamides due to what ADR?
Photosensitivity sun fearing =**s**ul**f**onamide :(
62
Prototype drug of Glycopeptides:
Vancomycin
63
mechanism of action of vancomycin
bactericidal, inhibits cell wall synthesis
64
what is vancomycin reserved for?
reserved for severe or resistant gram-positive infection; effective for MRSA infections, used to treat C.Difficile
65
# 5 things Adverse reactions for Vancomycin
1. ototoxicity (balance and dizziness), 2. nephrotoxicity (**NOT** hepatotoxic), 3. red man syndrome, 4. confusion/hallucinations, 5. anaphylaxis *
66
3 characteristics of super infections:(
1. Free from competition from bacteria that were sensitive to the drug, the mutated bacteria thrives. 2. The client now develops an infection that is resistant to conventional therapy. 3. This resistant bacteria can be transmitted to others.
67
abx kill a).. bacteria. In superinfections, only b).. bacteria is left.
a) sensitive b) insensitive
68
# 4 abx Methicillin-Resistant Staphylococcus-Aureus (MRSA) Will NOT respond to
tetracyclines, macrolides, fluoroquinolones, aminoglycosides | Too many fucking antibiotics
69
When an organism is resistant to more than one drug =
= multidrug-resistant 
70
Using a single, specific antibiotic may:
- Reduce antagonism - Reduce resistance * | narrow spectrum range
71
four signs and symptoms of a super infection
- Diarrhea (pseudomembranous colitis or c.diff) - Bladder pain & Painful urination (e.coli/UTI) - Abnormal vaginal discharge (yeast - Candida) - Red rash with satellite lesions (yeast - Candida)
72
# 3 things Why should all antidiarrheals, antibiotics and proton pump inhibitors be stopped?
1. Antidiarrheals may mask treatment failure or worsening diarrhea 2. Overuse of Antibiotic therapy for coexisting conditions may lead to C. Difficile 3. Proton Pump inhibitors may increase risk for C.Difficile
73
# 2 things If antibiotic overuse can lead to C. Difficile, then why is it ordered for treatment?
1. For mild to moderate C. Diff, Metronidazole PO/NG routes mean it will stay longer in the gut thus provide the best treatment. IV routes are not as effective. 2. Once it becomes severe, oral or rectal Vancomycin is the best treatment
74
What Abx has a category X pregnancy rating
Sulphonamides
75
What antibiotic will cross into breastmilk?
fluroquinolones