Antibiotics

Question 1

What class is Piperacillin/Tazobactam (Zosyn)?

Answer 1

Extended-spectrum penicillin + Beta-lactamase inhibitor

Question 2

What is the mechanism of action of Piperacillin/Tazobactam (Zosyn)?

Answer 2

Piperacillin: Inhibits PBPs → Weakens bacterial cell wall → Bactericidal; Tazobactam: Beta-lactamase inhibitor → Protects piperacillin from degradation

Question 3

What bacteria does Piperacillin/Tazobactam (Zosyn) cover?

Answer 3

Gram-positives (Streptococcus, MSSA), Gram-negatives (Pseudomonas, Enterobacter, Klebsiella), Anaerobes (Bacteroides fragilis)

Question 4

What bacteria does Piperacillin/Tazobactam (Zosyn) NOT cover?

Answer 4

ESBL-producing bacteria, Carbapenem-resistant Enterobacteriaceae (CRE/KPC bacteria), MRSA

Question 5

What are the clinical indications for Piperacillin/Tazobactam (Zosyn)?

Answer 5

Serious infections: Pneumonia, Sepsis, Intra-abdominal infections, UTIs, Skin & soft tissue infections

Question 6

What is the route of administration for Piperacillin/Tazobactam (Zosyn)?

Answer 6

IV only (not oral)

Question 7

What should be monitored during IV administration of Piperacillin/Tazobactam (Zosyn)?

Answer 7

IV site for phlebitis, Compatibility with other IV drugs (e.g., aminoglycosides)

Question 8

What are the main side effects of Piperacillin/Tazobactam (Zosyn)?

Answer 8

Allergic reactions (cross-reactivity with penicillins), Low toxicity overall

Question 9

What are the key nursing considerations for Piperacillin/Tazobactam (Zosyn)?

Answer 9

Same as Penicillin G, plus: Monitor IV site carefully, Check for drug interactions with aminoglycosides