Antibiotics Flashcards

0
Q

All macrolides inhibit CYP450 except?

A

Azithromycin

has the highes Vd and slowest elimination

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1
Q

SE Toothenamel dysplasia/discoloration

A

TeTracycline

(Blocks aTTachment of Trna to acceptor site

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2
Q

Drug used for Macrolide resistance

A

Telithromycin

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3
Q

________ for anaerobic infxns ABOVE

________ for anaerobic infxns BELOW

A

Clindamycin

Metronidazole

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4
Q

Post antibiotic effect are seen in?

A

Aminoglycosides and Flouroquinolones

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5
Q

Narrowest therpeutic window among Aminoglycosides

A

Amikacin

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6
Q

Aminoglycoside that can cause Hepatic Encepalopathy

A

Neomycin

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7
Q

Most ototoxic Aminoglycoside

A

Kanamycin, Amikacin

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8
Q

For drug resistant Gonorrhea or penicillin allergies

A

Spectinomycin

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9
Q

Most vestibulotoxic

A

Tobramycin, Gentamycin

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10
Q

Drug that reaches high concentration in Prostatic and Vaginal fluid

A

Trimethoprim

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11
Q

Inhibitor of Dihydroptoate synthase

Inhibitor of Dihydrofolate Reductase

A

Sulfonamides

Trimethoprim

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12
Q

Dihydropteroate Synthase inhibitor used for BuRNs

A

Sliver Sulfadiazine

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13
Q

SE Bone Cartilage damage

A

Flouroquinolones

Ciprofloxacin

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14
Q

Widest spectrum of activity in Flouroquinolones

A

Moxifloxacin

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15
Q

Most important drug in TB

A

Isoniazid

16
Q

Prevent neurotoxicity in TB drugs by giving ________

A

Pyridoxine Vit B6

17
Q

SE of Anti leprosy drug Dapsone

A

Methemoglobinemia, acute hemolysis in G6PD, fever, skin rashes, git disturbance

18
Q

SE of Ampotheracin B

A

infusion reaction
Nephrotoxicity
RTA with Magnesium And Potassium wasting