Antibiotics

Question 0

What are the drugs that inhibit cell membrane synthesis? (3)

Answer 0

Daptomycin
Polymyxin B
Colistimethate

Question 1

What are the antibiotics that inhibit cell wall synthesis? (9)

Answer 1

Penicillins
Cephalosporins
Monobactam
Carbapenams
Glycopeotide
Lipoglycopeptides
Bacitracin
Cycloserine
Isoniazid

Question 2

What is the drug that broadly inhibits protein synthesis (ie does not target a ribosome subunit specifically)?

Answer 2

Nitrofurantoin

Question 3

What are the drugs/drug classes that inhibit the 50S ribosome? (6)

Answer 3

Chloramphenicol 
Macrolides
Ketolide
Lincosamides
Oxalodinones
Streptogramins

Question 4

What are the drugs/drug classes that inhibit the 30S ribosome? (4)

Answer 4

Tetracyclines
Glycylcycline
Aminoglycosides
Spectinomycin (D/C)

Question 5

What is the drug class that inhibits DNA-dependent RNA polymerase?

Answer 5

Rifamycins

Question 6

What is the drug class that inhibits DNA supercoiling and synthesis?

Answer 6

Quinolones

Question 7

What is the drug class that binds DNA and causes cell death?

Answer 7

Metronidazole

Question 8

What are the drugs that are antimetabolites?

Answer 8

Bactrim

Question 9

What drugs are used for MRSA? (8)

Answer 9

Vancomycin
Telavancin
Daptimycin
Linezolid
Synercid
Bactrim
Ceftaroline
Tigecycline

Question 10

What drug is used for VRE?

Answer 10

Linezolid

Question 11

What are the concentration-dependent killers? (2)

Answer 11

Aminoglycosides

Lipoglycopeptides (Telavancin)

Question 12

Clavulonic acid pairs with

Answer 12

Amoxicillin and Ticarcillin

Question 13

Sulbactam pairs with

Answer 13

Ampicillin and Cefoperazone

Question 14

Tazobactam pairs with

Answer 14

Piperacillin

Question 15

Four types of penicillins

Answer 15

Natural
Penicillinase resistant
Amino penicillins
Extended spectrum

Question 16

Examples of penicillinase resistant penicillins

Answer 16

Methicillin
Naficillin
Oxacillin
Cloxacillin
Dicloxacillin

Question 17

Examples of amino penicillins

Answer 17

Ampicillin

Amoxicillin

Question 18

Example of monobactam

In the beta lactam group

Answer 18

Aztreonam

Question 19

What drugs have the beta lactam in their core structure?

Answer 19

Penicillins
Cephalosporins
Monobactam
Carbapenams

Question 20

What are the drugs that are neurotoxic? (5)

Answer 20

Aminoglycosides 
Polymixins
Carbapenams
Cycloserine
Colistimethate

Question 21

What are the drugs that are hepatotoxic? (4)

Answer 21

Rifampin
Isoniazid
Cycloserine
Telithromycin

Question 22

What are the drugs that are ototoxic?

Answer 22

Vancomycin

Aminoglycosides

Question 23

What are the drugs that are nephrotoxic? (5)

Answer 23

Aminoglycosides
Vancomycin 
Colistimethate
Bacitracin
Polymixins

Question 24

Which drug causes Gray Syndrome?

Answer 24

Chloramphenicol

Question 25

Which drug is an MAOI?

Answer 25

Linezolid

Question 26

Which drug turns body fluids red/orange/brown?

Answer 26

Rifampin

Question 27

Which drug class is for pen-resistant pneumoniae?

Answer 27

Streptogramins

Question 28

Which drug is for MDR pneumoniae?

Answer 28

Telithromycin

Question 29

Which drugs are primary alternatives if a patient has a beta lactam allergy?

Answer 29

Macrolides | Clindamycin

Question 30

What are the first and second line agents for TB?

Answer 30

First line Rifampin and Isoniazid Second line Cycloserine

Question 31

Which drug class can cause tendon ruptures and what are the risk factors?

Answer 31

Fluroquinolones | >60, transplant, steroid use

Question 32

Which drugs cause photosensitivity?

Answer 32

Bactrim | Tetracyclines

Question 33

Which drug causes phototoxicity?

Answer 33

Fluoroquinolones

Question 34

Which drugs cause infusion reactions? (3)

Answer 34

Vancomycin Linezolid Telavancin

Question 35

Which drugs require a long infusion time?

Answer 35

Vancomycin Telavancin Linezolid Fluroquinolones

Question 36

Which drugs prolong the QT interval?

Answer 36

Macrolides Ketolide Fluroquinolones Synercid

Question 37

Drugs that treat C. diff (3)

Answer 37

Metronidazole Fidaxomycin Oral vancomycin

Question 38

Drugs that chelate (3)

Answer 38

Chloramphenicol Tetracyclines Fluoroquinolones

Question 39

What is the spectrum of activity for first generation cephalosporins?

Answer 39

Gram positive and modest gram negative

Question 40

What is the spectrum of activity for second generation cephalosporins?

Answer 40

Gram positive and increased gram negative

Question 41

What is the spectrum of activity for third generation cephalosporins?

Answer 41

``` Less gram positive and more gram negative Space bugs (pseudomonas) ```

Question 42

What is the spectrum of activity for fourth generation cephalosporins?

Answer 42

Gram positive and gram negative--broadest spectrum to date | Pseudomonas

Question 43

What is the spectrum of activity for fifth generation cephalosporins?

Answer 43

Less gram positive and more gram negative | MRSA

Question 44

What is the spectrum of activity for natural penicillins?

Answer 44

Gram positive

Question 45

What is the spectrum of activity for penicillinase resistant penicillins?

Answer 45

Staph infections

Question 46

What is the spectrum of activity for amino penicillins?

Answer 46

Gram positive and modest gram negative

Question 47

What is the spectrum of activity for extended spectrum penicillins?

Answer 47

Gram positive and extended gram negative | Proteus and pseudomonas

Question 48

Which drugs/drug classes are enzyme inhibitors?

Answer 48

``` Chloramphenicol Erythromycin Clairithromycin Telithromycin Synercid Metronidazole Isoniazid Ciprofloxaxin Quinolones ```

Question 49

Which drugs that are enzyme inhibitors are noncompetitive irreversible inhibitors?

Answer 49

Macrolides | Chloramphenicol

Question 50

Which drug class is an enzyme inducer?

Answer 50

Rifamycins

Question 51

Which drugs are good for gram positive infections?

Answer 51

``` Vancomycin Telavancin Daptomycin Linezolid Synercid Bactrim Ceftaroline Tigecycline Penicillins ```

Question 52

Which drugs are good for gram negative infections?

Answer 52

Colistimethate Aminoglycosides Polymixins Aztreonam

Question 53

Which drugs have gram positive and some gram negative activity?

Answer 53

Macrolides Amino penicillins First generation cephalosporins

Question 54

Which drugs are good for pseudomonas? (7)

Answer 54

``` Fluoroquinolones Aminoglycosides Ceftazidime (third gen) Extended spectrum penicillins Carbapenams Aztreonam Cefepime (fourth gen) ```

Question 55

Which drugs cover atypical infections?

Answer 55

Macrolides Fluoroquinolones Tetracyclines

Question 56

Which drugs are mainly for anaerobes?

Answer 56

Metronidazole | Clindamycin

Question 57

Which drugs are good for bone infections?

Answer 57

Linezolid | Cephalosporins

Question 58

Examples of Macrolides

Answer 58

Azithromycin Clarithromycin Erythromycin Fidaxomycin

Question 59

Example of the workhorse lincosamide

Answer 59

Clindamycin

Question 60

Drugs that are basic

Answer 60

Macrolides | Chloramphenicol

Question 61

Examples of oxalodinones

Answer 61

Linezolid | Tedizolid

Question 62

Examples of streptogramins

Answer 62

Synercid Quinupristin Dalfopristin

Question 63

Examples of tetracyclines

Answer 63

Demeclocycline Doxycycline Minocycline Tetracycline

Question 64

Glycylclines

Answer 64

Tigecycline