Antibiotics Flashcards Preview

Biochemistry > Antibiotics > Flashcards

Flashcards in Antibiotics Deck (23):
1

Streptomycin

prokaryotes, initiation
binds to 30S subunit, distorting it

2

Tetracyclines

prokaryotes, elongation
Binds to 30S subunit, blocks entry of AA-tRNA to A side

3

Chloramphenicol

prokaryotes, elongation,
Inhibits peptidyltransferase

4

Clindamycin
Erythromycin

prokaryotes, elongation,
Binds to 50S subunit, blocks translocation

5

Diptheria Toxin

eukaryotes, elongation,
inactivates elongation factor, blocks translocation

6

Cycloheximide

eukaryotes, elongation
may bind to E site and block translocation

7

Puromycin

both, elongation
AA-tRNA analogue, causes peptide chain termination

8

Bevacizumab (Avastin™)

monoclonal antibody that binds VEGF and blocks it from binding to VEGF receptors on the surface of vascular endothelial cells.

9

Name the 3 drugs that inhibit the kinase activity of VEGF-R

Sunitinib (Sutent™)
Sorafenib (Nexavar™)
Cederanib (Recentin™ - AZD- 2171)

10

Rifampicin

used in Tb, inhibits initiation of transcription in prokaryotes
binds to Beta subunit of holoenzyme, inhibits formation of first phosphodiester bond

11

Actinomycin D

chemotherapy
inhibits elongation of RNA transcription.. binds to DNA

12

a-amanitin

binds to RNA Pol II, symptoms 24 hours, death in week

13

Trichostatin A

Histone Deactylase Inhibitor = mood stabilizer, anti-epipleptic; reactivates gene!

14

Ovarian Dermoid Cyst

ALL FEMALE

15

Hydatidiform Mole

All Male

16

XIC

X Inactivation Center contains a gene, Xist, which is directly responsible for X inactivation.
Xist makes RNA PRODUCT, not protein, and coats inactive X with it.

17

Prader WIlli

loss of paternal 15q11.12-q13.1 expression
you don't have PWS gene turned on- underexpression of SNRPN

18

Vector Must:

1. be capable of autonomous replication
2. must contain 1 unique restriction site
3. must have 1 gene that confers the ability to select for the vector

19

Herceptin

Her2 inhibitor that treats Her2 breast cancer

20

Tamoxifen

treats progesterone breast cancer

21

Erlotinib and Afatinib

treat EGFR mutations in NSCLC

22

crizotinib + certinib

treat ALK rearrangements in NSLCLC

23

nivolumab

monoclonal antibody that treats squamous NSCLC