Flashcards in Antibiotics Deck (23):
binds to 30S subunit, distorting it
Binds to 30S subunit, blocks entry of AA-tRNA to A side
Binds to 50S subunit, blocks translocation
inactivates elongation factor, blocks translocation
may bind to E site and block translocation
AA-tRNA analogue, causes peptide chain termination
monoclonal antibody that binds VEGF and blocks it from binding to VEGF receptors on the surface of vascular endothelial cells.
Name the 3 drugs that inhibit the kinase activity of VEGF-R
Cederanib (Recentin™ - AZD- 2171)
used in Tb, inhibits initiation of transcription in prokaryotes
binds to Beta subunit of holoenzyme, inhibits formation of first phosphodiester bond
inhibits elongation of RNA transcription.. binds to DNA
binds to RNA Pol II, symptoms 24 hours, death in week
Histone Deactylase Inhibitor = mood stabilizer, anti-epipleptic; reactivates gene!
Ovarian Dermoid Cyst
X Inactivation Center contains a gene, Xist, which is directly responsible for X inactivation.
Xist makes RNA PRODUCT, not protein, and coats inactive X with it.
loss of paternal 15q11.12-q13.1 expression
you don't have PWS gene turned on- underexpression of SNRPN
1. be capable of autonomous replication
2. must contain 1 unique restriction site
3. must have 1 gene that confers the ability to select for the vector
Her2 inhibitor that treats Her2 breast cancer
treats progesterone breast cancer
Erlotinib and Afatinib
treat EGFR mutations in NSCLC
crizotinib + certinib
treat ALK rearrangements in NSLCLC