Antibiotics

Question 1

3rd gen cephalosporins:
( Cefotaxime - iv; Ceftazidime - iv
Ceftriaxone - iv; Cefixime - po; Cefdinir - po) do not cover?

Answer 1

Poor gram-positive coverage
E. faecium
MRSA
All cover MSSA EXCEPT ceftazidime
Legionella / atypicals
Listeria
Acinetobacter
Not all cover Pseudomonas

Question 2

3rd gen cephalosporins cover?

Answer 2

Expanded gram-negative coverage
Oral anaerobes
S. aureus (MSSA)
Strep pneumoniae
Strep Grp A,B,C,G
Strep viridans
Gram negative rods
N. gonorrhea
All cover B. fragilis EXCEPT cefotaxime & ceftazidime

Question 3

4th gen cephalosporin - cefepime

Answer 3

Good gram-positive & gram-negative coverage
Anti-Pseudomonal (including ceftazidime resistant isolates)
Penetrates CSF
Limited anaerobic coverage