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Flashcards in Antibiotics Deck (33):
1

Sulfonamides have resistance to

Pseudomonas
Bacteroides
Enterococcus

2

Sulfonamides work for Gram ___

Neg and Pos

3

How do sulfonamides work

Block production of folic acid

4

How do potentiated sulfas work

Block PABA and dihydrofolate reductase

5

Sulfonamides are highly restricted for

Dairy cattle

6

How do beta lactams work

Bind to penicillin binding proteins (cell lysis)

7

Examples of beta lactams

Penicillin
Cephalosporin

8

3rd Generation cephalosporins penetrate ___

The CNS

9

T/F: Beta Lactams can be used extra label

True

10

How does Tetracycline work

Binds 30s ribosome preventing protein synthesis

11

Characteristics of tetracycline

lipophilic, wide distribution, accumulate intracellularly

12

Neomycin and gentamicin are

Aminoglycosides

13

Aminoglycosides are effective against gram ___

Negative

14

Aminoglycosides are highly ___ soluble and poorly ___ soluble

Highly water soluble
Poorly lipid soluble

15

Where do aminoglycosides accumulate

lysosomes and mitochondria causing a post-antibiotic effect

16

Where do aminoglycosides accumulate

lysosomes and mitochondria causing a post-antibiotic effect

17

Aminoglycosides can cause toxicity to

Kidney and ear

18

T/F: Aminoglycosides are commonly used

FALSE: they are a zero tolerance drug and are strongly urged not to be used except for neonatal pigs

19

What is Florfenicol most commonly used for

BRD, keratoconjunctivitis, Foot Rot

20

How does Florfenicol work

Blocks peptidyltransferase on 50s ribosome

21

Why is Florfenicol good for H. Somni

Achieves concentration in CNS above MIC for 20 hrs --- penetrates diseased lung more than healthy lung

22

Is extra label use allowed for florfenicol

Yes

23

Erythromycin is what drug class

Macrolide

24

Macrolides have ___ activity

intracellular -- higher positive charge

25

Macrolides are especially good for which bacteria

Mycoplasma

26

How do macrolides work

Bind 50s ribosome

27

Where do macrolides accumulate

Cells more acidic than plasma
Lysosomes of leukocytes

28

Why should lincosamides be avoided in foregut/hindgut fermenters

cause clostridial overgrowth

29

Lincosamides are best for which species

Swine

30

How do lincosamides work

bind 50s ribosome

31

Lincosamides work best for which bacteria

Strep, erysipelothrix, mycoplasma

32

T/F: Fluoroquinolones are highly restricted

TRUE

33

what are examples of fluoroquinolones

Enrofloxacin