Antibiotics Flashcards
(109 cards)
1
Q
Aminopenicillin
A
Amoxicillin
2
Q
Cefazolin use
A
Surgical site infections
3
Q
Quinupristin-dalfopristin side effects
A
- hyperbilirubinemia
- arthralgia
- phelbitis
4
Q
Amoxicillin use
A
URI
5
Q
Macrolides use
A
Respiratory tract infections
Atypical
Peptic ulcer
6
Q
Inhibit DNA topoisomerase
A
Fluoroquinolones
7
Q
Aztreonam use
A
Pseudomonas
8
Q
Drug of choice for CDAD
A
Metro
9
Q
BBW avoid with MAOIs
A
Linezolid
10
Q
Side effects of chloramphenicol
A
Gray baby syndrome
Aplastic anemia
BM suppresion
11
Q
Cipro use
A
UTIs Gastroenteris Antrax Plague Influenzae
12
Q
Tetracycline MOA
A
Bacteriostatic
30S
Inhibit binding tRNA to A —> prevent addition of AA
13
Q
Vanco use
A
MRSA
CDAD
14
Q
Anti-staph penicillin
A
Nafcillin
15
Q
Fidaxomicin use
A
C diff
Alternative to metro and vanco
Lower risk of recurrence
16
Q
Drugs decreased kidney function
A
Aminoglycosides Vanco Cephalo SMX/TMP Penicillin Carbapenems Aztreonam
17
Q
Alternative for metronidazole for CDAD
A
Vanco
18
Q
Doxycycline use
A
Atypicals
Tick
Peptic ulcer
Malaria
19
Q
TMP/SMX MOA
A
bactericidal
20
Q
Quinupristin-dalfopristin use
A
MRSA
VRE
21
Q
Fosfomycin use
A
UTIs
22
Q
Inhibit RNA polymerase
A
Fidaxomicin
23
Q
Doxycycline side effects
A
- teeth
- superinfection
- photosensitive
24
Q
Respiratory FQ
A
Cipro
25
Standard penicillin
Pen g
26
SMX MOA
Bacteriostatic
Competitive inhibitor of dihydropteroate synthesis
Prevents DNA replication
27
BBW carcinogenic in animals
Metro
28
Tigecycline BBW
Increase all cause mortality
29
Nitroimdazole MOA
Bactericidal
Prodrug
Reduction of nitro group
30
Side effects of imipenem-cilastatin
N/D
Hypersensitivity
Seizures
31
Bind 30S
Aminoglycosides
| Tetracyclines
32
Only cephalosporin active against MRSA
Ceftaroline
33
Fluoroquinolone MOA
Inhibit topoisomerases
Bactericidal
34
Cefepime use
Nosocomial
| Febrile neutropenia
35
Linezolid MOA
23s RNA of 50S
36
Imipenem-cilastatin use
MSSA
| MDR
37
Clindamycin MOA
Bacteriostatic
50S
Block peptide formation
38
BBW MG
Cipro
39
Biliary sludging
Ceftriaxone
40
Time dependent
Cell wall inhibitors
Macrolides
Tetracycline
41
Chloramphenicol BBW
Blood dyscrasias
42
Aminoglycosides use
Endocarditis
Serious G- infections
Tularemia & plague
- UTIs
43
Which drugs have a prolonged cardiac QT?
Macrolides
| Fluoroquinolones
44
SMX side effects
Kernicterus
Rash & SJS
Hemolytic anemia (G6PD)
45
Anti-pseudomonal penicillin
Piperacillin-tazobactam
46
Tetracyclines
Doxycycline
| Tigecycline
47
Macrolides
Azithromycin
| Clarithromycin
48
TMP side effects
BM suppression
| Hyperkalemia
49
Macrolides MOA
Bacteriostatic
50S
Inhibit translocation of protein elongation
50
Which drug is mainly used outside of the US?
Chloramphenicol
51
TMP use
UTIs
| Otitis media
52
Chloramphenicol use
Outside of US: MRSA, VRE
US: meningitis
53
Alternative to extended spec penicillin and aminoglycosides
Aztreonam
54
Post-antibiotic effect
Aminoglycosides
Amikacin/gentamicin
55
Peak concentration dependent
Aminoglycosides
| Fluoroquinolones
56
1st gen ceph
Cefazolin
57
DI metro
Ethanol: disulfiram like reaction
58
Drug can’t be taken with dairy
Tetracyclines
| Fluorquinolones
59
Jarisch Herxheimer
Pen G
60
4th gen ceph
Cefepime
61
Linezolid side effects
- myelosuppresion
- neuropathy
- lactic acidosis
62
Inhibitor of transglycosylation
Glycopeptides
63
Ceftaroline use
MRSA
64
Fosfomycin MOA
- inhibit murein monomers in cytosol
- glycerophosphate transporter
- bactericidal
65
Chloramphenicol MOA
50S
Inhibit binding tRNA to A
In liver
66
BBW increase all cause mortality
Tigecycline
67
Inhibitor of transpeptidation
Beta lactam
68
Vanco MOA
Block Nam-Nag
69
Metro BBW
Carcinogenic in animals
70
DI with doxycyline
With Pen G against pneumo meningitis
71
Inhibit folic acid synthesis
sulfonamides
| Trimethoprim
72
Linezolid BBW
Avoid with MOAIs
73
TMP/SMX side effects
Well tolerated
HIV S
Same as individual drugs
74
DNA damage
Metronidazole
75
Fluoroquinolone
Cipro
76
Quinupristin-dalfopristin MOA
D: 23S RNA of 50S
Q: 50S
Bactericidal
77
Cipro side effects
CDAD
Hepatotoxicity
Photosensitive
Hypoglycemia
78
Drugs decreased liver function
```
Clindamycin
Macrolides
Chloramphenicol
Tetracycline
Metro
```
79
TMP MOA
Bacteriostatic
Prevent reduction of dihydrofolate to form THF
Prevent DNA replication
80
Nafcillin use
MSSA
81
Non-allergic maculopapular rash
Amoxicillin
82
Metronidazole use
```
CDAD
Anaerobic
Bacterial vag
Peptic ulcer
Parasites
```
83
Aminoglycosides side effects
Ototoxicity
Nephrotoxicity
NM blockade
84
3rd gen ceph
Ceftriaxone
85
AUC dependent
Tetracycline
| Vancomycin
86
BBW clindamycin
CDAD
| May develop after withdrawn
87
Aminoglycosides
Amikacin
| Gentamicin
88
BBW blood dyscrasias
Chloramphenicol
89
Inhibitor of murein presursor synthesis
Fosfomycin
90
BBW tendon rupture
Cipro
91
2nd gen ceph
Cefoxitin
92
Metro side effects
```
HA
GI
Metallic taste
Dark red brown urine
Neuropathy
```
93
Piperacillin-tazobactam use
PEK (pseudomonas, enterobacter, klebsiella
94
TMP/SMX use
- UTIs
MDR
Pneumonia
95
Bind 50S
Macrolides
Chloramphenicol
Clindamycin
96
Vano side effects
- ototoxic
- nephrotoxic
- red man syndrome
97
5th gen ceph
Ceftaroline
98
Tigecycline use
MRSA & VRE
99
Linzeolid use
MDR
VRE
MRSA
100
Avoided during pregnancy
```
Aminoglycosides
Tetracycline
Sulfonamide
Trimethoprim
Fluoroquinolones
```
101
Aztreonam resistance
Highly resistant to most B-lactamases
Except KPC
102
BBW CDAD
Clindamycin
103
What drug has transporter to cytosol?
Fosfomycin
104
Ceftriaxone use
Meningitis
105
Amoxicillin-clavulante use
Mixed infections
Nosocomial
URI
106
Aminoglycosides MOA
Bactericidal
16S within 30S
Irreversible
Premature termination of protein synthesis
107
Fidaxomicin MOA
RNA pol inhibitor
| Bactericidal
108
Cipro BBW
Tendon rupture
| MG
109
Clindamycin use
MRSA
Acne
Bacterial vaginosis
