Antibiotics Flashcards
(39 cards)
Antibiotics are
antimicrobial agents naturally produced by a variety of
bacteria and fungi
What’s their job?
or kill other microorganisms.
Less than __% of known antibiotics are clinically useful
1
Antibiotics can be modified to enhance efficacy the name of that?
semisynthetic antibiotics
Gram-positive and Gram-negative bacteria vary in their ____ to
______
- sensitivity
- antiobiotics
why is there a big diference in gram - and gram +?
the cell wall is a major factor
b-Lactams are one?
the most important groups of antibiotics of all time.
b-lactams include?
penicillins, cephalosporins, and cephamycins.
who discovered penicilins?
Alexander Fleming
he isolatede that ?
from Penicillium
chrysogenum
Penicillins is primarily effective against?
Gram-positive bacteria
some synthetic forms of penicilling are effective against?
some Gram-negative bacteria
what’s the job of penicillins?
Inhibit cell wall synthesis
what’s important in penicillin?
the b-lactam ring
natural penicilin the moiety is?
benzylpenicillin
ni penicilin can the moiety be changed?
Yes, it can
Name of semisynthetic penicilin?
- Methicillin
- Oxacillin
- Ampicillin
- Carbenicillin
Cephalosporins is produced by?
the fungus cephalosporium
what is the mode of actiion of cephalosporins?
same mode of action as the penicillins
cephalosporins is commonly used to treat ?
gonorrhea
Mode of actino of b-lactams as to do with?
transpeptidase enzyme
transpeptidase enzyme is a ?
penicillin‐binding protein
β‐lactams are?
- bactericidal
- bacteriolytic
being bactericidal or bacteriolytic depends on?
the specie,growth phase, etc
