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Flashcards in Antibiotics Deck (15)
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1
Q

statin interaction

A

clarithromycin

rhabdomyolysis

2
Q

methotrexate interaction

A

trimethoprim

BM suppression

3
Q

warfarin interaction

A

clarithromycin
(raises INR)
(increases EFFECT of warfarin)

erythromycin
(enzyme inhibitor)
(↑ INR)
(↑ warfarin effect)

4
Q

steroids interaction

A

fluroquinolone

achilles tendon rupture

5
Q

metronidazole interaction

A

alcohol

V & flushing

6
Q

COCP interaction

A

TB drugs - rifampicin, isoniazid

pregnancy risk

7
Q

what to prescribe for UTI?

A

nitrofurantoin (avoid in renal dysfunction)

trimethoprim (teratogenic in 1st trimester)

8
Q

what to try and do when prescribing Abx?

A

write the indication
write a stop/review days
(generally 3 days for IV)

9
Q

Abx for meningitis?

A

cefotaxime (TAX the meningitis)

10
Q

Abx for neutropenic sepsis (neutrophils <1)?

A

IV tazocin

11
Q

Tx bacterial meningitis?

A

ABC, O2
IV fluids, blood cultures
IV 2g cefotaxime (pre-LP if delayed > 1hr)
LP when stable (+/- CT head)
IV dexamethasone (if stiff neck, suspected ↑ICP)
+/- ITU

12
Q

Abx used to treat bone infection with S/E of abx colitis?

A

clindamycin

13
Q

S/E co-amoxiclav?

A

cholestatic jaundice can commonly, or very commonly occur, either during or shortly after treatment with co-amoxiclav

risk of acute liver toxicity was about 6 times greater with co-amoxiclav than with amoxicillin

14
Q

Tx of scarlet fever (macular red rash, strawberry tongue, red throat, fever >38.3°C)?
(“secondary case of invasive group A streptococcal infection”)

A
  • phenoxymethylpenicillin 125 mg PO 6-hrly for 10 days
  • if has tolerated oral fluid, oral antibiotics
  • 10 day course
15
Q

when is gentamicin contraindicated?

A

Myasthenia gravis (aminoglycosides may impair neuromuscular transmission)