ANTIBIOTICS Flashcards

(51 cards)

1
Q

Antibiotics/ Penecillins

A

Amoxicillin
Amoxicillin/Clavulanate (Augmentin)
Piperacillin/Tazobactam (Zosyn)

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2
Q

Antibiotics/ Penecillins INDICATION

A

Common for broad coverage of Gram- and Gram+

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3
Q

Antibiotics/ Penecillins ROA

A

PO, IV

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4
Q

Antibiotics/ Penecillins MOA

A

inhibit cell wall synthesis

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5
Q

Antibiotics/ Penecillins AE

A

GI, hypersensitivity/allergies

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6
Q

Antibiotics/ Cephalosporins

A

Cephalexin (Keflex)

Cephtriaxone (Rocephin)

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7
Q

Antibiotics/ Cephalosporins INDICATION

A

Cephalexin: surgical prophylaxis, SSTIs

Cephtriaxone: surgical prophylaxis, community-acquired pneumonia, meningitis, gonorrhea, severe Lyme disease

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8
Q

Antibiotics/ Cephalosporins MOA

A

inhibit cell wall synthesis

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9
Q

Antibiotics/ Cephalosporins AE

A

GI, hypersensitivity

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10
Q

Antibiotics/ Cephalosporins PK/PD

A

Caution for severe and immediate PCN allergy due to cross-reactivity

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11
Q

Antibiotics/ Cephalosporins OTHER

A

Cephalexin: 1st generation
Cephtriaxone: 3rd generation

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12
Q

Antibiotics/ Glycopeptides

A

Vancomysin

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13
Q

Vancomysin INDICATION

A

MRSA, C. diff, increasing resistance (VRE)

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14
Q

Vancomysin ROA

A

IV, PO for C. diff

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15
Q

Vancomysin MOA

A

inhibit cell wall synthesis

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16
Q

Vancomysin AE

A

Hypotension, red man syndrome, nephrotoxicity

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17
Q

Antibiotics/ Aminoglycosides

A

Gentamicin

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18
Q

Gentamicin INDICATION

A

Gram- bacilli, staph, myobacteria

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19
Q

Gentamicin ROA

A

IV, PO, inhaled, topical, ophthalmic, intraventricular (CSF shunt)

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20
Q

Gentamicin MOA

A

inhibit bacterial protein synthesis

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21
Q

Gentamicin AE

A

Ototoxicity, nephrotoxicity

22
Q

Antibiotics/ macrolides

A

Azithromycin (Z-pack)

23
Q

Azithromycin (Z-pack) INDICATION

A

Some Gram+ and Gram-, pneumonia, respiratory infections, CAP

24
Q

Azithromycin (Z-pack) ROA

A

PO, IV, ophthalmic

25
Azithromycin (Z-pack) MOA
inhibit bacterial protein synthesis
26
Azithromycin (Z-pack) AE
Common: N/V/D QT prolongation, CYP450 inhibitors (DDI)
27
Antibiotics/ Tetracycline
Doxycycline
28
Doxycycline INDICATION
Broad coverage of Gram+ and Gram- and atypicals PNA, SSTIs, Lyme, bite wounds, STIs
29
Doxycycline ROA
PO, IV
30
Doxycycline MOA
inhibit bacterial protein synthesis
31
Doxycycline AE
Typically tolerated well, yellowing of teeth GI, photosensitivity
32
Doxycycline OTHER
Contraindicated in pregnant & breast-feeding women and children under 8
33
Antibiotics/ Lincosamide
Clindamycin
34
Clindamycin INDICATION
Gram+, SSTIs, anaerobic intra-abdominal infections, acne
35
Clindamycin ROA
topical for acne
36
Clindamycin AE
GI (D), can cause C. diff
37
Antibiotics/ Fluoroquinolines
Ciprofloxacin | Levofloxacin (Levaquin)
38
Fluoroquinolines INDICATION
Gram-, pneumonia, chronic bronhitis, CAP, STIs, anthrax, plague, prostatitis, bite wounds, TB, diabetic foot ulcers, SSTIs
39
Fluoroquinolines ROA
PO, IV, ophthalmic, otic
40
Fluoroquinolines MOA
inhibit bacterial DNA synthesis or break down DNA strands
41
Fluoroquinolines AE
Generally tolerated well. GI, phototoxicity RARE: tendon rupture, significant hypoglycemia
42
Fluoroquinolines OTHER
Boxed Warning s do not apply to opthalmic routes reserved for serious systemic infections due to risks
43
Antibiotics/ Nitroimidazole
Metronidazole (Flagyl)
44
Nitroimidazole INDICATION
Anaerobes, C. diff, bacterial vaginosis, Chron's disease, pelvic inflammatory disease, GI infections
45
Nitroimidazole ROA
PO, IV
46
Nitroimidazole MOA
inhibit bacterial DNA synthesis or break down DNA strands
47
Nitroimidazole AE
HA, vaginitis, nausea, metallic taste Less Common: peripheral neuropathy, vomit with alcohol
48
Antibiotics/ Antifolates
Sulfamethoxazole/Trimethoprim (Bactrim)
49
Antifolates INDICATION
Broad coverage of Gram+ and Gram-, UTIs, infectious diarrhea, alternative MRSA treatment
50
Antifolates MOA
inhibit bacterial DNA synthesis or break down DNA strands
51
Antifolates AE
can cause allergy Rare but serious derm reactions: Toxic Epidermal Necrolysis, Stevens-Johnson syndrome