Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Top 300 > Antibiotics Chapter > Flashcards

Antibiotics Chapter Flashcards

(50 cards)

Start Studying
1
Q

Moa

50 S protein synthesis inhibitors

A

Macrolides
Clindamycin
Oxalolidiones (Linezolid)
Streptogramins (quinopristin/dalfopristin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Moa

Cell wall inhibitors (bacteriocodal)

A

Penicillins, cephalosporins, carbapenams, vancomycin, monobactans, fosfomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Dna/ rna inhibitors (bacteriocodal)

A

FQ (dna gyrase/topoisomerase)
Rifampin
Flagyl

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Call membrane inhibitors (bacteriocidal)

A

Polymixins (colisitin)

Daptomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Folic acid synthesis inhibitors: bacteriostatic alone, but cidal in combination

A

Sulfonamides and trimethoprim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Concentration dependent drugs

A

AG
FQ
Daptomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Time dependent drugs

A

Cephalosporins
Carbapenams
B-lactams

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Auc :mic

A

Vancomycin
Macrolides
Tetracyclines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Hydrophilic agents

A 
Beta lactams 
AG 
Glycopeptides 
Daptomycin 
Colistin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Lipophillic agents

A 
FQ 
Macrolides
Rifampin 
Linezolid
Tetracyclines 
Chloeamphenicol
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Moa

30 S protein synthesis inhibitors

A

AG and tetracyclines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Seizures with accumulation ; allergic reactions

A

Beta-lactams

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Ototoxic, infusion reactions (redmans syndrome)

A

Vancomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Additive QTc interval, muscle toxicity, phlebitis, D5W only

A

Synercid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Interaction with statins due to increase cPK

A

Daptomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Turns urine red

A

Rifampin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

BBW: colitis

A

Clindamycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Serotonin syndrome (can’t use with SSri, MAO-I, and HTN crisis patients (sympathininetics), BMS

A

Linezolid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Contraindicated with CrCL

A

Nitrofurantoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Avoid during 3rd trimester. Allergic reactions and photosensitive

A

Bactrim

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Avoid during first trimester

22
Q

Increase neuromuscular blockers, Ototoxic based on dose

23
Q

BBW: tendonitis, additive QT c, photosensitive, cations ***

24
Q

Additive QTc and hepatic toxicity

25
Cations and photosensitive
Tetracyclines
26
CNS/meningitis
``` Streptococcus pneumonia Neisseria gonorrheoae H. Influenza Streptococci/E. Coli (young) Listeria (young/old) ```
27
Abelcet
Amphotericin B lipid complex
28
AmBisome
Liposomes Amphotericin B
29
Amphotec
Amphotericin B cholesteryl sulfate complex
30
The conventional aphotericin formulation
Amphotericin B desoxycholate
31
Fluconazole IV/PO
1:1
32
What is ketoconazold more likely used for?
Androgen related disorders due to its anti-androgenic activity
33
Can itraconazole capsules and solutions be changed interchangeably?
No
34
How take itraconazole capsules?
With food. Requires gastric acidity for absorption
35
How take itraconazole solution?
More bioavailability than capsules. Take on an empty stomach
36
What is the DOC for treating Aspergillus?
Voriconazole
37
Which two antifungals have pH dependent absorption?
Itraconazole and ketoconazole Don't use with antacids!!!
38
All Azole antifungals are ______inhibitors
3A4
39
What is voriconazoles big adverse effect?
Visual changes. Caution driving at night. Avoid direct sunlight
40
What electrolytes do you need to correct before starting voriconazoles?
K+, Ca2+, Mg 2+
41
Voriconazoles follows what kinetics?
1st order followed by Michaelis-Menten non-linear kinetics
42
Caspofungin can cause bad ___
Hepatotoxicity
43
Inhibit synthesis of B (1,3) - D - glucagon. Fungicidal
Echinocandins
44
List the Echinocandins
Caspofungin Micafungin Anidulafungin
45
Bind to ergosterol, altering cell membrane permeability in susceptible fungi and causing cell death ; fungicidal
Amp B
46
Penetrates fungal cells and is converted to flourouracil which competes with uracil, interfering with fungal RNA and protein synthesis ;fungicidal
Flucytosine Don't use as monogherapy. use with amp B to have synergy
47
Decrease ergosterole synthesis and inhibit cell membrane formation and are typically fungistatic, but may be fungicidal for select fungal pathogens
Azole antifungals
48
What Does posaconazole cover that Vori does not?
Zygomycosis/Mucor
49
Neuramindase inhibitors
Tamiflu (oseltamivir) Zanamivir (Relenza)
50
Neuramidase inhibitors affect _________of viral particles
The release

Top 300 (30 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions