Antibiotics For H.pylori Infections

Question 1

Name the drugs used in H.pylori eradication

Answer 1

Amoxicillin, metronidazole, clarithromycin

Question 2

Amoxicillin indication

Answer 2

H.pylori eradication (1st line)
UTI
Acute sinusitis

Question 3

Amoxicillin Precautions

Answer 3

Cephalosporin allergies, patients with HIV and heart conditions (aspartame)

Question 4

Amoxicillin Adverse effects

Answer 4

Common = diarrhoea, constipation, nausea, superinfections

Rare = black tongue, hypernatremia, hypokalaemia, neurotoxicity

Question 5

Clarithromycin Precautions

Answer 5

Renal impairment, drug can prolong QT interval

Question 6

Clarithromycin Contraindications

Answer 6

Treatment with cisapride, colchicine, Domperidone

Question 7

Clarithromycin Adverse effects

Answer 7

Common = taste disturbances, nausea, vomiting, candidal infection, diarrhoea

Rare= pulmonary infiltration with eosinophils, hypersensitivity, ototoxicity, prolonged QT interval

Question 8

Clarithromycin indication

Answer 8

Non-TB mycobacterial infections
H.pylori eradication
Lower respiratory infections

Question 9

Metronidazole Indication

Answer 9

Protozoan infection
Dental infection
H.pylori infection
Bacterial vaginosis

Question 10

Metronidazole Precautions

Answer 10

History of CNS disorders (seizures) = worsen
Past disulfiram use
Drug accumulation in renal and hepatic impairment

Question 11

Metronidazole contraindications

Answer 11

Cockayne syndrome
Use w/ fluorouracil
Allergic reactions

Question 12

Metronidazole Adverse Reactions

Answer 12

Commons = nausea, anorexia, metallic taste, CNS effects, vomiting diarrhoea

Rare = hypersensitivity reaction, hepatitis, pancreatitis, peripheral neuropathy