Antibiotics/fungal/virus

Question 1

Penicillinase-sensitive penicillins

Answer 1

Amoxicillin
Ampicillin
Aminopenicillins
Pen G/V
Piperacillin
Ticarcillin

Question 2

Penicillinase-resistant penicillins

Answer 2

Dicloxacillin
Nafcillin
Oxacillin

Question 3

Antipseudomonal penicillins

Answer 3

Piperacillin
Ticarcillin
Use with beta-lactamase inhibitor

Question 4

Beta-lactamase inhibitors

Answer 4

Clavulanic acid
Avibactam
Sulbactam
Tazobactam

Question 5

Beta-lactams

Answer 5

Penicillins
Cephalosporins
Carbapenems

Question 6

Cell wall synthesis inhibitors–peptidoglycan synthesis

Answer 6

Glycopeptides: vancomycin and bacitracin

Question 7

Cell wall synthesis inhibitors: peptidoglycan cross-linking

Answer 7

Beta-lactams

Question 8

Protein synthesis inhibitors: 50S subunit

Answer 8

Chloramphenicol
Clindamycin
Linezolid 
Macrolide S
Streptogramins (quinupristin and Adolfo priest in)

Question 9

Protein synthesis inhibitors: 30S subunit

Answer 9

Aminoglycosides
Glycyclines (tigecycline)
Tetracyclines

Question 10

Folic acid synthesis and reduction inhibitors: DNA methylation

Answer 10

Sulfonamides

Trimethoprim

Question 11

DNA gyrase inhibitors

Answer 11

Fluoroquinolones

Quinolone (nalidixic acid)

Question 12

MRNA synthesis inhibitor (RNA polymerase)

Answer 12

Rifampin

Question 13

DNA integrity inhibitor (makes free radicals)

Answer 13

Metronidazole

Question 14

Mycolic acid synthesis inhibitor

Answer 14

Isoniazid

Antimycobacterial

Question 15

Arabinogalactan synthesis inhibitor (arabinosyl transferase)

Answer 15

Ethambutol

Antimycobacterial

Question 16

Mycobacterial mRNA synthesis inhibitor (DNA-dependent RNA polymerase)

Answer 16

Rifabutin

Rifampin

Question 17

Mycobacterial intracellular

Answer 17

Pyrazinamide

Mechanism unknown

Question 18

Lanosterol synthesis inhibitor

Answer 18

Terbinafine

Antifungal

Question 19

Ergosterol synthesis inhibitors

Answer 19

Azoles

Antifungal

Question 20

Fungal cell wall synthesis

Answer 20

Echinocandins (anidulafungin/caspofungin/micafungin)

Question 21

Fungal cell membrane integrity inhibitor

Answer 21

Polyenes (amphotericin B, nystatin)

Question 22

Fungal nucleic acid synthesis inhibitor

Answer 22

Flucytosine

Question 23

Antihelminthic therapy

Answer 23

Mebendazole (microtubule inhibitor)
Pyrantel pamoate 
Ivermectin
Diethylcarbamazine
Praziquantel

Question 24

Chloroquine

Answer 24

Treatment of plasmodia species other than P falciparum

Blocks detoxification of heme into hemozoin (heme toxic to plasmodia)

Question 25

Anti-mite/louse therapy

Answer 25

Permethrin (depolarization via Na channels) Malathion (AChE inhibitor) Lindane (blocks GABA channels--neurotoxicity)

Question 26

Toxoplasmosis treatment

Answer 26

Pyrimethamine

Question 27

Trypanosoma brucei

Answer 27

Suramin and melarsoprol

Question 28

T Cruzi

Answer 28

Nifurtimox

Question 29

Leishmaniasis

Answer 29

Sodium stibogluconate

Question 30

Viral protein synthesis inhibitors

Answer 30

Interferon-alpha (HBV/HCV)

Question 31

Viral uncoating inhibitors

Answer 31

Amantadine Rimantadine NOT used any more (resistance)

Question 32

Viral nucleic acid synthesis inhibitors

Answer 32

Guanosine analogs: acyclovir, etc (HSV/VZV), ganciclovir (CMV) Viral DNA polymerase inhibitors: cidofovir (acyclovir-resistant HSV), foscarnet (CMV) Guanine nucleotide synthesis: ribavarin (RSV/HCV)

Question 33

Release of viral progeny inhibitors

Answer 33

Neuraminidase inhibitors: oseltamivir/zanamivir (influenza A/B)

Question 34

NRTIs

Answer 34

``` Abacavir Didanosine Emtricitabine Lamivudine Stavudine Tenofovir--only nucleoTide Zidovudine ```

Question 35

NNRTis

Answer 35

Delavirdine Eva Irene Nevirapine

Question 36

HIV attachment inhibitor

Answer 36

Maraviroc

Question 37

HIV penetration inhibitor

Answer 37

Enfuvirtide

Question 38

Integrase inhibitor

Answer 38

Dolutegravir Elvitegravir Raltegravir

Question 39

Protease inhibitors

Answer 39

``` Atazanavir Darin air Fosamprenavir Indinavir Lopinavir Ritonavir Saquinavir ```

Question 40

Sulfonamides and P

Answer 40

Kernicterus

Question 41

Aminoglycosides and P

Answer 41

Ototoxicity

Question 42

Fluoroquinolones and P

Answer 42

Cartilage damage

Question 43

Clarithromycin and P

Answer 43

Embryotoxic

Question 44

Tetracyclines and P

Answer 44

Discolored teeth | Inhibition of bone growth

Question 45

Ribavirin and P

Answer 45

Teratogenic

Question 46

Griseofulvin and P

Answer 46

Teratogenic

Question 47

Chloramphenicol and P

Answer 47

Gray baby syndrome