Antibiotics. Summary Flashcards

1
Q

What penicillinase resistant penicillins are used for in ruminants?

A

Gram+ mastitis

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2
Q

Penicillins in ruminants:

A
  • narrow sp.: airway infection, foot diseases, wounds, mastitis
  • broad spectrum penicillins: airway infection, foot diseases, mastitis
  • penicilinase resistant penicillins: gram+ mastitis
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3
Q

Cephalosporins in ruminants

A

1,2 gen: gram+ mastitis
3,4 gen: airway infections, foot diseases, mastitis

from 3 gen ceftiofur and cefoperazone are used

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4
Q

AGs in ruminants:

A
  • all -> diarrhea in calves, lambs
  • GENTA, SPECTINO -> airways
  • NEO, GENTA -> mastitis, metritis
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4
Q

Tetracyclines in ruminants

A
  • airway infecrions, foot diseases, mastitis (IV)
  • wounds, infectious KC, enzootic abortion

injection + topical + per os (calf, lamb)

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5
Q

Phenicols in ruminants:

A

airway infections

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6
Q

Macrolides in ruminants

A

Tilmicosin, Tildipirosin -> airway infections
Tulathromycin, gamithromycin -> airway infections + foot diseases, infectious KC

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7
Q

Lincosamides, pleuromutilins in ruminants

A
  • Lincomycin -> foot diseases, mastitis, airway infections?
  • Tiamulin -> airway infections?
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8
Q

Potentiated SAs in ruminants

A
  • decreasing usage
  • airway infections
  • mastitis (IV)
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9
Q

Fluorquinolones in ruminants

A
  • airway infections
  • mastitis
  • GI tract infections
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10
Q

Drugs for treatment mastitis in ruminants:

A
  • penicillins
  • cephalosporins
  • NEOmycin, GENTAmycin
  • tetracyclines
  • lincomycin
  • potentiated SAs
  • fluoroquinolones
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11
Q

Drugs NOT used for treating mastitis in ruminants:

A
  • phenicols
  • macrolides
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12
Q

Infections caused by GRAM+ bacteria in swine

A
  • Clostridium perfringens C - porcine necrotic enteritis
  • Clostridium perfrigens A - 6 week old piglet’s diarrhea
  • Staphylococcus hyicus - exudative epidermitis
  • Staphylococcus aureus - dermatitis, metritis, mastitis, etc
  • Streptococcus suis - septicaemia, meningitis, arthritis
  • Erysipelothrix rhusiopathiae - swine erysipelas
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13
Q

Infections caused by GRAM– bacteria in swine

A
  • Pasteurella multocida - atrophic rhinitis, pneumonia, septicaemia
  • Bordetella bronchiseptica - atrophic rhinitis, bronchopneumonia
  • Actinobacillus pleuropneumoniae - necrotic pleuropneumonia
  • Glaeserrella parasuis - Glasser disease (fibrinic polyserositis, arthritis)
  • Lawsonia intracellularis - proliferative enteropathie, ileitis
  • Brachyspira hyodysenteria - swine dysenterie
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14
Q

Infections caused by Mycoplasma species in swine

A
  • Mycoplasma hyopneumoniae - pneumonitis
  • Mycoplasma hyorhinis - polyserositis, arthritis
  • Mycoplasma hyosynoviae - arthritis
  • Mycoplasma suis - anaemia, fever, abortion, hemolysis
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15
Q

Infections caused by other bacteria species in swine

A
  • Salmonella - enterocolitis
  • Leptospira - abortion, mumies, dead fetuses
  • Actinobaculum - cystitis, pyelonephritis
  • Campylobacter - enterocolitis
  • Clamydia - enteritis, pneumonia, abortion
  • Lysteria - septicaemia, encephalitis, abortion
  • Treponema - necrosis of the tip of the ear, dermatitis, foot disease
16
Q

Infections in swine that can be treated by penicillins

A

Amoxicillin: - IM, PO
- swine erysipelas
- Clostridium perfrigens
- Streptococcus suis
- Glasser disease
- Actinobacillus pleuropneumonia (APP)
- Pasteurella multocida
- Postpartum dysgalactia syndrome (PDS) - MMA: mastitis, metritis, agalactia

Amoxiclav: - SC, IM, PO
- Bordetella bronchiseptica
- enteritis caused by E. coli, Salmonella
- Staphylococcus

Narrow penicillins:
procaine, benzatine - IM
- swine erysipelas
- Streptococcus suis
- Trueperella pyogenes
- Pasteurella multocida
phenoxymethil-penicillin (PO) - Clostridium perfrigens A, C

17
Q

What are gram negaive bacteria that are rare lactamase producers?

A
  • Pasteurella multocida
  • Actinobacillus pleuropneumoniae
  • Glaeserrella parasuis

So amoxicillin, not amoxiclav (AMEG C)

18
Q

What AB group targets aerobic gram— bacteria?

A

Aminoglycosides

19
Q

What antibiotics are prohibited to used with myorelaxants?

A

Aminoglycosides

20
Q

What causes infectious keratoconjunctivitis?

A

Moraxella bovis
Tetracyclines (MAYBE SG MORE)

21
Q

What AB group has very high IC concentration because of ion-trapping?

A

Macrolides. (Also tetracyclines and phenicols have good IC conc but not as good as macrolides)

22
Q

Examples of IC bacteria. (Check bacteriology lectures)

A
  • Chlamydia
  • Mycoplasma
  • Rickettsia
23
Q

What is 1st choice drug to treat Rhodococcus equi infection in foals?

A

Erythromycin (macrolide)
Separate mare and foal!!!

24
Q

What drug causes dose-independent anaemia ?

A

Chloramphenicol -> prohibited in food-producers