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ImmunoSero Continuation > Antibodies > Flashcards

Antibodies Flashcards

(92 cards)

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1
Q

Domain of immunoglobulin that is responsible for the specificity of the antibody.

A

Variable Region

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2
Q

It is the specific portion in the variable
region where antigen binding takes place

A

HYPERVARIABLE PORTION/ REGION

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3
Q

Domain of immunoglobulin that binds with the complement proteins specifically the C1q

A

CH2 (Constant Heavy Chain 2)

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4
Q

Domain of immunoglobulin that is responsible for the cytotropic reactions involving macrophage, monocytes, mast cells, Cytotoxic Killer Cells and B cells

A

CH3 (Constant Heavy Chain 3)

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5
Q

Domain of immunoglobulin that is responsible for the light chain type of the antibody

A

CL (Constant Light Chain)

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6
Q

The light chain type can either be a ______ or ______.

A

Kappa; Lambda

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7
Q

What is the percentage of light chain that is classified as Kappa?

A

65%

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8
Q

Kappa is predominantly present in _______

A

Ab

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9
Q

What are the 5 classes of immunoglobulins?

A

(GAMDE) IgG, IgA, IgM, IgD, IgE

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10
Q

What is the percentage of light chain that is classified as Lambda?

A

35%

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11
Q

The predominant Ig in healthy human serum

A

IgG

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12
Q

What are the 4 subclasses of immunoglobulin G?

A

IgG1, IgG2, IgG3, IgG4

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13
Q

What is the antibody that has the longest half-life or circulation life?

A

IgG

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14
Q

What is the antibody that is predominant in the secondary or the anamnestic response?

A

IgG

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15
Q

What is the antibody that provides immunity to the newborn?

A

IgG

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16
Q

What is the only antibody that can actively cross the placenta?

A

IgG

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17
Q

What is the antibody that can provide neonatal immunity? - IgG

A

IgG

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18
Q

What is the antibody that is considered as the best precipitating antibody?

A

IgG

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19
Q

Why can IgG actively cross the placenta?

A

because it is the smallest antibody

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20
Q

The subclasses of IgG that can actively cross placental

A

IgG1 & IgG3

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21
Q

True or False. IgG is a cold-reacting antibodies.

A

False. It is warm- reacting

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22
Q

True or False. IgG participates in agglutination and precipitation

A

True

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23
Q

True or False. IgG optimally reacts at room temperature.

A

False. @37°C

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24
Q

Tell the percentage of the stated IgG sublass in the circulation and its corresponding number of disulfide bonds: IgG1

A

66%; 2

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25
Tell the percentage of the stated IgG sublass in the circulation and its corresponding number of disulfide bonds: IgG2
23%; 4
26
Tell the percentage of the stated IgG sublass in the circulation and its corresponding number of disulfide bonds: IgG3
7%; 15
27
Tell the percentage of the stated IgG sublass in the circulation and its corresponding number of disulfide bonds: IgG4
4%; 2
28
It is a pentameric immunoglobulin
IgM
29
The antibody that is first to appear in phylogeny and the last to leave in senescence
IgM
30
The antibody that is first appear after a primary antigenic stimulus
IgM
31
True or False. IgM is a warm-reacting antibodies that reacts at ref temperature (4°C)
False. IgM is cold-reacting antibody that reacts at ref temperature (4°C)
32
True or False. IgM is a cold-reacting antibodies.
True
33
What are the functions of IgM?
Complement fixation, Agglutination reaction, Opsonization, Neutralization of toxin
34
The antibody that is considered as the best agglutinating antibody
IgM
35
IgM in agglutination reaction can initiate________
Lattice Formation
36
The antibody that is responsible for mucosal immunity
IgA
37
The antibody, aside from IgG, that is transferred by the mother thru colostrum
IgA
38
The antibody that the function is still unknown but believes to play a role in immunoregulation
IgD
39
IgA exist as monomer in ______ and dimer in ______
Blood; Secretion
40
What are the 2 subclasses of immunoglobulin A?
IgA1, IgA2
41
It is responsible for maintaining the IgA structure in the secretion by preventing enzymatic degradation of the antibody structure
secretory component
42
How does the secretion component of IgA maintain its structure?
by preventing enzymatic degradation of the antibody structure
43
The antibody that can be found on the surface of B- lymphocytes
IgD
44
The antibody that is postulated to be an anti-idiotypic antibody
IgD
45
The antibody that is least abundant in the serum
IgE
46
IgE is originally known as ______
Reaginic antibody
47
Heat-labile antibody, originally known as Reaginic antibody
IgE
48
This antibody binds strongly to mast cell (tissues) and basophil (intravascular circulation) receptor
IgE
49
This antibody mediates some types of hypersensitivity reactions
IgE
50
Histamine released is due to the binding to the attached allergen of what type of immunoglobulin
IgE
51
This type of antibody is released during helminthic infection
IgE
52
Molecular weight of IgG in Daltons
150T
53
Molecular weight of IgA in Daltons
160-400T
54
Molecular weight of IgM in Daltons
900T
55
Molecular weight of IgD in Daltons
180T
56
Molecular weight of IgE in Daltons
190T
57
Half-life of IgG
21-23 days
58
Half-life of IgA
5-6 days
59
Half-life of IgM
5 days
60
Half-life of IgD
2-3 days
61
Half-life of IgE
2-3 days
62
How many subclasses do IgG have?
4
63
How many subclasses do IgA have?
2
64
How many subclasses do IgM have?
2
65
How many subclasses do IgD have?
None
66
How many subclasses do IgD have?
None
67
How many domains do IgG have?
4
68
How many domains do IgA have?
4
69
How many domains do IgM have?
5
70
How many domains do IgD have?
4
71
How many domains do IgE have?
5
72
Does IgG activate complement?
Yes (specifically Classical Pathway), except IgG4
73
Does IgA activate complement?
Alternative pathway only (Provided that IgA is in aggregate s for it to elicit or induce the activation )
74
Does IgM activate complement?
Yes (specifically Class ical Path way) , most efficient
75
Does IgD activate complement?
no
76
Does IgE activate complement?
No
77
What is the major Ig in 2° Immune response?
IgG
78
Immunoglobulins characterized of having J chains
IgA & IgM
79
Antibody involved in B cell activation
IgD
80
Antibody that is Heat & Acid Labile
IgD
81
Antibody that is susceptible to enzyme degradation
IgD
82
Antibody that is associated with Immediate hypersensitivity
IgE
83
Antibody that binds basophils and mast cells
IgE
84
Antibody that is elevated during parasitic infections
IgE
85
Other name of IgG
Serum Ig
86
Other name of IgA
secretory Ig
87
Other name of IgM
Pentameric Ig
88
Other name of IgE
Reagenic Ig
89
True or False. Pentameric Ig is also known as IgA
Pentameric Ig is IgM
90
True or False. Secretory Ig is also known as IgG
False. Secretory Ig is IgA
91
True or False. Serum Ig is also known as IgA
False. Serum Ig is IgG
92
True or False. Reagenic Ig is also known as IgM
False. Reagenic Ig is IgE

ImmunoSero Continuation (2 decks)

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