Antibodies

Question 1

What are the different isotopes of antibody?

Answer 1

IgM
IgG
IgA
IgD
IgE

Question 2

What is the function of IgM in an immune response?

Answer 2

Main antibody of primary responses
Best at fixing compliment
Monomer form of IgM acts as the B cell receptor

Question 3

What is the function of IgG in an immune response?

Answer 3

Main blood antibody of secondary responses
Neutralises toxins
Opsonisation

Question 4

What is the function of IgA in an immune response?

Answer 4

Secreted into mucas, tears, saliva and colostrum

Question 5

What is the function of IgE in an immune response?

Answer 5

Antibody of allergy and antiparasitic activity

Question 6

What is the function of IgD in an immune response?

Answer 6

B cell receptor

Question 7

What are the functions of antibodies?

Answer 7

To function as the B cell receptor
Neutralise viruses
Neutralise toxins
Bind to pathogen surface and activate classical complement
Oponisation

Question 8

Antibodies neutralising viruses

Answer 8

Bind to the surface proteins of the virus

This blocks it from attaching and entering a host cell

Question 9

How do antibodies activate compliment?

Answer 9

IgM or multiple IgG antibodies

Bind to a pathogen surface and act as a platform for the C1 complex to begin the classical pathway

Question 10

Antibody role in opsonisation

Answer 10

Acts with certain immune cells that express Fc receptors which bind to the constant domain of the antibody heavy chain
Cell binds to antibodies and engulfs them and the bound pathogen
Put in a vesicle and phagocytosed