Antibodies

Question 1

Anti GM-CSF

Answer 1

Pulmonary alveolar proteinosis

Question 2

Anti-La

Answer 2

Sjogrens

Question 3

Anti centromere

Answer 3

Limited scleroderma / CREST

Question 4

Anti-dsDNA

Answer 4

Specific for SLE

Question 5

Anti-Jo1

Answer 5

Polymyositis

Question 6

Anti-U1RNP

Answer 6

Mixed connective tissue disease

Question 7

Anti-Smith

Answer 7

SLE, specific

a/w renal and neurological lupus

Question 8

Anti-topoisomerase (Anti-SCL70)

Answer 8

Diffuse Scleroderma, associated with ILD

Question 9

Anti-histone

Answer 9

Drug induced lupus SLE

Question 10

Anti-CCP

Answer 10

RA, specific

Question 11

C-ANCA (anti-PR3)

Answer 11

Wegner’s / Granulomatosis with Polyangitis

Question 12

P-ANCA (anti MPO)

Answer 12

Microscopic Polyangitis,

P-ANCA negative Eosinophilic granulomatosis with Polyangitis

Question 13

Anti-SRP

Answer 13

Polymyositis - highly aggressive, poor response to immunosuppression

Can also be seen in necrotizing autoimmune myositis

Question 14

Anti-RNA polymerase III

Answer 14

Scleroderma, a/w renal disease

Question 15

Anti-Ro60/SSA

Answer 15

Sjogrens
Neonatal lupus erythematous
Subcutaneous cutaneous lupus erythematous (SCLE)

Question 16

Anti-U3-RNP

Answer 16

Diffuse scleroderma, pulmonary arterial hypertension, myositis

Question 17

Anti-Th/To

Answer 17

Limited scleroderma

Question 18

Anti-PM-SCL

Answer 18

Myositis

Question 19

Anti-La / SSB

Answer 19

Sjogrens

Neonatal lupus erythematous

Question 20

Anti-synthetase

Answer 20

Anti-synthetase syndrome including ILD, arthritis, fever, Raynaud phenomenon, mechanic’s hands

Question 21

Anti-Mi-2

Answer 21

Dermatomyositis

Question 22

Anti-smooth muscle antibody

Answer 22

Primary Biliary Cholangitis

Question 23

Voltage-gated potassium channel (VGKC)-complex antibodies

Answer 23

Anti-LGI1
Limbic encephalitis, Morvan syndrome (neuromyotonia, memory loss and confusion, sleep disturbances, autonomic instability), neuromyotonia, faciobrachial dystonic seizures

Anti-Caspr2 associated encephalitis
Caspr2 plays a role in maintaining normal role of VgKC
Variable presentation

Question 24

Anti Purkinje antibody
Anti-Yo antibody
Purkinje cell cytoplasmic antibody Type 1 (PCA-1)

Answer 24

Target are the cerebellar degeneration related proteins that are expressed by Purkinje cells and ovarian and breast cancers
= paraneoplastic cerebellar degeneration

Question 25

Anti-NMDA

Answer 25

Anti-NMDA receptor encephalitis Features: prominent psychiatric manifestations, insomnia, memory deficits, seizures, decreased LOC, frequent dyskinesias, autonomic instability, language dysfunction

Question 26

Anti-aquaporin 4

Answer 26

Neuromyelitis optica spectrum disorders Disease specific serum NMO-IgG antibody that selectively binds aquaporin-4 Features: acute attacks of bilateral or rapidly sequential optic neuritis (severe visual loss) or transverse myelitis (limb weakness, sensory loss, bladder dysfunction)

Question 27

Anti-GAD

Answer 27

Glutamic acid decarboxylase | T1DM

Question 28

Anti-MuSK (muscle specific kinase)

Answer 28

AChR-Ab negative Myasthenia Gravis

Question 29

Anti-amphiphysin

Answer 29

Stiff-person syndrome Features: progressive muscle stiffness, rigidity, spasm involving the axial muscles Caused by increased muscle activity due to decreased inhibition of the CNS that results from blockade of glutamic acid decarboxylase (GAD), an enzyme critical for maintaining inhibitory pathways.

Question 30

Anti voltage gated calcium channel antibodies (VGCC)

Answer 30

Lambert Eaton Myasthenic Syndrome (LEMS) Features: slowly progressive proximal muscle weakness

Question 31

Anti-GM1

Answer 31

Multifocal motor neuropathy | Also elevated in Guillain-Barre

Question 32

HMG CoA reductase antibodies

Answer 32

Immune mediated necrotizing myopathy secondary to statin use

Question 33

Anti-MDA5 (melanoma differentiation associated gene 5)

Answer 33

Rapidly progressive Interstitial lung disease Predominant cutaneous features A/w dermatomyositis

Question 34

Anti-SRP

Answer 34

Inflammatory myopathies | Associated with poorer prognosis - severe myopathy and end organ failure

Question 35

Anti DFS70 association

Answer 35

Positively results means unlikely to be SLE | Dense fine speckled

Question 36

Anti Hu

Answer 36

``` Paraneoplastic SCLC and neuroblastoma Painful sensory neuropathy Encephalomyelitis Cerebellar Syndrome ```

Question 37

Anti Yo

Answer 37

Paraneoplastic Syndrome Breast and ovarian cancer Cerebellar Syndrome

Question 38

Anti-Ri

Answer 38

Paraneoplastic Syndrome Breast and SCLC Occular opsoclonus-myoclonus

Question 39

Anti-GAD

Answer 39

Breast, colorectal and SCLC | Stiff persons syndrome, hypertonia