Antibodies in Rheumatology

Question 1

anti-CCP

cyclic citrullinated peptide

Answer 1

Rheumatoid Arthritis

Question 2

Anti-centromere

Answer 2

CREST syndrome

limited systemic sclerosis

Question 3

Anti-Jo-1

one type of synthetic synthetase

Answer 3

Polymyositis/ dermatomyositis

Question 4

Anti-Scl-70 (anti DNA topoisomerase)

Answer 4

Systemic Sclerosis, diffuse

Question 5

Anti-RNA polymerase

anti-U3 RNP

Answer 5

Systemic Sclerosis, esp with renal crisis)

Question 6

Anti-U1 RNP

anti-RNP not otherwise specified

Answer 6

Mixed connective tissue disorder

Question 7

Anti-Smith

anti-Sm

Answer 7

SLE

Question 8

anti-dsDNA

Answer 8

SLE

Question 9

ANA

Answer 9

Lupus and many other rheumtatic diseases

* so not specific at all

Question 10

Anti-SSA is the same as

Answer 10

anti-RO

Question 11

anti-SSA (anti-Ro)

Answer 11

Sjogren syndrome, neonatal lupus, subcutaneous lupus

Question 12

anti-SSB is the same as

Answer 12

anti-La

Question 13

anti-SSB (anti-La)

Answer 13

Sjorgen Syndrome, neonatal lupus, subcutaneous lupus

Question 14

Pauci-immune diseases

Answer 14

Microscopic polyangiitis, eosinophillic granulomatosis with polyangiitis (Churg Strauss), Granulomatosis with polyangiitis (wegener’s)

Question 15

Anti-myeloperoxidase is the same thing as

Answer 15

perinuclear anti-neutrophil cytoplasmic antibody

P-ANCA

Question 16

Anti-myeloperoxidase

P-ANCA

Answer 16

Microscopic Polyangiitis
Churg Strauss (eosinophillic granulomatosis with polyangiitis)

Question 17

Anti-proteinase 3 is the same thing as

Answer 17

diffuse cytoplasmic anti-neutrophil cytoplasmic antibody

C-ANCA

Question 18

Anti-proteinase 3

C-ANCA

Answer 18

granulomatosis with polyangiitis (Wegener’s)

Question 19

small vessel vasculitis

Answer 19

Henloch Schonlein Purpura
Infections
Drug Rxns
Auto-immune dx? (SLE)
Malignancy Associated
Idiopathic?
(palpable purpura, blisters, maybe urticaria)

Question 20

Pure Medium Vessel Vasculitis

Answer 20

Polyarteritis Nodosa
(nodules, purpura, livedo reticularis, ulcers, necrosis)

Question 21

Large vessel Vasculitidies

Answer 21

Giant Cell arteritis
Takayatsu aortitis
Behcet’s
(likely no skin manifestations)

Question 22

Mixed small/medium vasculitities

Answer 22

> P-ANCA (Churg-Strauss and Microscopic Polyangiitis)
C-ANCA (Wegener’s)
Cryoglobulinemic Vasculitis