Flashcards in Antibodies To Things Deck (56):
Ds-DNA (double stranded DNA)
MOST highly specific for SLE
What Ab can you order with a high sensitivity for SLE?
*a/w high specificity for SLE
*predicts lupus nephritis
*correlates with disease severity
What antibody do you order which is a/w lupus nephritis in SLE?
Double-stranded DNA or Anti-Sm
*also anti-Smith does as well
*ds-DNA has a high specificity for SLE, predicts disease severity, correlates with early/severe disease
A/w lupus nephritis, highly specific for SLE
*So is anti-dsDNA
Anti-rRNP (U1 RNP)
R-RNP - Highly specific for neuropsychiatric LE *per Jain
U1 RNP - Highly specific for MCTD *per Hocker
What antibody do you test if you are suspicious for neuropsychiatric LE?
SJOGRENS!(Most strong association)
Neonatal lupus/congenital heart block
What antibodies do you order to check for SCLE
*also a/w congenital heart block
Anti-SSA,Anti-SSB is the same Ab as what?
*checks for SCLE/neonatal lupus/congenital heart block/ AND Sjogrens
Antibody to check for neonatal lupus?
Anti-Ro/La (same thing as SSA/SSB)
Strongest Ab a.w Sjogrens
*MOST SPECIFIC -Anti fodrin
*which are also a/w SCLE/neonatal lupus
What two diseases is anti-Ro/La a/w?
SJOGRENS (strong) (sidenote* anti-fodrin is most specific)
*also can see in SCLE but mostly MCTD
Drug induced SLE
Antibody indicating drug induced SLE/SCLE
SLE with polymyositis
Antibody for drug induced polymyositis
Increased risk of SLE in DLE
What antibody would you order in a DLE patient to assess their possible risk for SLE?
Anti-dsDNA is most specific test for SLE
Anti-ssDNA is risk of SLE within a DLE patient
Test for antiphospholipid syndrome in SLE
Most SPECIFIC for Sjogrens!!!
*also strong is anti-Ro/La
Which Ab a/w systemic disease and lymphoma in Sjogrens
Anti Ro (other Ab associated w Sjogrens are Ro/La and Fodrin)
Same thing as DNA-topoisomerase I (seen in systemic sclerosis)
Anti-Scl-70 is the same this as what antigen
DNA topoisomerase I. (Seen in severe systemic sclerosis)
Ab most strongly a/w diffuse skin disease in systemic sclerosis
Anti-Scl-70 (DNA topoisomerase I)
Ab a/w CREST
Anti-RNA Polymerase III
Severe skin and KIDney disease in systemic sclerosis
*RNA polymerase the third, is part of a long family line with lots of KIDS, severe punishment for bad kids
Marker for severe renal and skin disease in systemic sclerosis
RNA polymerase III
same thing as U3RNP, marker for pulmonary HTN in systemic sclerosis
*remember U1RNP is marker of SLE and also MCTD
Marker for pulmonary HTN in systemic sclerosis
Anti-fibrillarin (same thing as U3RNP)
Same thing as anti-fibrillarin
*marker for internal organ involvement in systemic sclerosis like pulmonary HTN
Name 4 antibodies you would check in evaluation a patient for systemic sclerosis besides ANA
RNA polymerase III
Cancer in dermatomyositis, amyopathic DM
Which Ab is a/w cancer in DM or amyopathic DM?
Anti-155 kDa (also called anti-Se)
Antisynthetase syndrome (DM w raynauds, mechanics hands, pulm fibrosis)
Ab for antisynthetase syndrome (in DM)
Cardiac involvement in DM (SRP*CPR**)
Hallmark skin lesions in DM, a/w good prognosis
Which Ab is a/w cardiac findings in DM
Which Ab is a/w typical DM skin lesions and carries a good prognosis?
Anti-juvenille DM with calcinosis
Juvenile DM with calcinosis Ab
Name all of the Ab you can think of a/w antisynthetase syndrome
The hallmark of antisynthetase syndrome is the presence of serum antibodies directed against which type of proteins?
Histidyl tRNA synthetases
Mi-2 is a good prognosis in which diseasE?
Which antibody carries a good prognosis in DM?
Ab for Cardiac involvement in DM
Cardiac involvement in DM
What cells are the substrate for indirect immunoflouresence in an ANA test?
Hep2 cancer cell line
What autoimmune disorder is least likely to have a positive ANA?
DERMATOMYOSITIS *only positive in 40-65%
*SLE has 99% positive ANA
Which antibody correlates with a lupus band test from SUN PROTECTED skin?