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Flashcards in Antibodies To Things Deck (56):
1

Ds-DNA (double stranded DNA)

MOST highly specific for SLE
Lupus nephritis

2

What Ab can you order with a high sensitivity for SLE?

Ds-DNA

*a/w high specificity for SLE
*predicts lupus nephritis
*correlates with disease severity

3

What antibody do you order which is a/w lupus nephritis in SLE?

Double-stranded DNA or Anti-Sm

*also anti-Smith does as well

*ds-DNA has a high specificity for SLE, predicts disease severity, correlates with early/severe disease

4

Anti-Sm

A/w lupus nephritis, highly specific for SLE

*So is anti-dsDNA

5

Anti-rRNP (U1 RNP)

R-RNP - Highly specific for neuropsychiatric LE *per Jain
U1 RNP - Highly specific for MCTD *per Hocker

6

What antibody do you test if you are suspicious for neuropsychiatric LE?

Anti-rRNP (U1RNP)

7

Anti-Ro (SSA)
Anti-La (SSB)

SJOGRENS!(Most strong association)
SCLE
Neonatal lupus/congenital heart block

8

What antibodies do you order to check for SCLE

Anti Ro(SSA)/La(SSB)
*also a/w congenital heart block

9

Anti-SSA,Anti-SSB is the same Ab as what?

Anti-Ro/Anti-La

*checks for SCLE/neonatal lupus/congenital heart block/ AND Sjogrens

10

Antibody to check for neonatal lupus?

Anti-Ro/La (same thing as SSA/SSB)

11

Strongest Ab a.w Sjogrens

Anti-Ro, Anti-La

*MOST SPECIFIC -Anti fodrin


*which are also a/w SCLE/neonatal lupus

12

What two diseases is anti-Ro/La a/w?

SJOGRENS (strong) (sidenote* anti-fodrin is most specific)
SCLE/neonatal lupus

13

Anti-U1RNP

MCTD
*also can see in SCLE but mostly MCTD

14

Anti-histone

Drug induced SLE

15

Antibody indicating drug induced SLE/SCLE

Anti-his tone

16

Anti-KU

SLE with polymyositis

17

Antibody for drug induced polymyositis

Anti-KU

18

Anti-ssDNA

Increased risk of SLE in DLE

19

What antibody would you order in a DLE patient to assess their possible risk for SLE?

Anti-ssDNA

20

Anti-dsDNA
Anti-ssDNA

Anti-dsDNA is most specific test for SLE
Anti-ssDNA is risk of SLE within a DLE patient

21

Anti-C1q

Severe SLE
*URTICARIAL VASCULITIS

22

Test for antiphospholipid syndrome in SLE

Anti-cardiolipin

23

Anti-Fodrin

Most SPECIFIC for Sjogrens!!!

*also strong is anti-Ro/La

24

Which Ab a/w systemic disease and lymphoma in Sjogrens

Anti Ro (other Ab associated w Sjogrens are Ro/La and Fodrin)

25

Anti-Scl-70

Same thing as DNA-topoisomerase I (seen in systemic sclerosis)

26

Anti-Scl-70 is the same this as what antigen

DNA topoisomerase I. (Seen in severe systemic sclerosis)

27

Ab most strongly a/w diffuse skin disease in systemic sclerosis

Anti-Scl-70 (DNA topoisomerase I)

28

Anti-centromere

CREST

29

Ab a/w CREST

Anti-centromere

30

Anti-RNA Polymerase III

Severe skin and KIDney disease in systemic sclerosis

*RNA polymerase the third, is part of a long family line with lots of KIDS, severe punishment for bad kids

31

Marker for severe renal and skin disease in systemic sclerosis

RNA polymerase III

32

Anti-fibrillarin

same thing as U3RNP, marker for pulmonary HTN in systemic sclerosis


*remember U1RNP is marker of SLE and also MCTD

33

Marker for pulmonary HTN in systemic sclerosis

Anti-fibrillarin (same thing as U3RNP)

34

U3RNP

Same thing as anti-fibrillarin

*marker for internal organ involvement in systemic sclerosis like pulmonary HTN

35

Name 4 antibodies you would check in evaluation a patient for systemic sclerosis besides ANA

Anti-
Centrome
Fibrillarin
Scl-70
RNA polymerase III

36

Anti-155 kDa/anti-Se

Cancer in dermatomyositis, amyopathic DM

37

Which Ab is a/w cancer in DM or amyopathic DM?

Anti-155 kDa (also called anti-Se)

38

Anti-Jo

Antisynthetase syndrome (DM w raynauds, mechanics hands, pulm fibrosis)

39

Ab for antisynthetase syndrome (in DM)

Anti-Jo

40

Anti-SRP

Cardiac involvement in DM (SRP*CPR**)

41

Anti-Mi2

Hallmark skin lesions in DM, a/w good prognosis

42

Which Ab is a/w cardiac findings in DM

Anti-SRP

43

Which Ab is a/w typical DM skin lesions and carries a good prognosis?

Anti-Mi2

44

Anti-p40

Anti-juvenille DM with calcinosis

45

Juvenile DM with calcinosis Ab

Anti-p140

46

Anti-PL-7, Anti-PL12

Antisynthetase syndrome

47

Name all of the Ab you can think of a/w antisynthetase syndrome

Anti-Jo
Anti PL-7
Anti PL-12
EJ/OJ

48

The hallmark of antisynthetase syndrome is the presence of serum antibodies directed against which type of proteins?

Histidyl tRNA synthetases

49

Mi-2 is a good prognosis in which diseasE?

DM

50

Which antibody carries a good prognosis in DM?

Mi2!

51

Ab for Cardiac involvement in DM

Anti-SRP

52

Anti-SRP

Cardiac involvement in DM

53

What cells are the substrate for indirect immunoflouresence in an ANA test?

Hep2 cancer cell line

54

What autoimmune disorder is least likely to have a positive ANA?

DERMATOMYOSITIS *only positive in 40-65%

*SLE has 99% positive ANA

55

Which antibody correlates with a lupus band test from SUN PROTECTED skin?

Anti-dsDNA

56

Antibody a\w amyopathic DM interstiatial lung disease

Anti-MDA-5

*BOARDS Q!!!!!!