anticancer drugs

Question 1

alkylating agent

Answer 1

cyclophosphamide
ifosfamide
mechlorethamine
dacarbazine
busulfan

Question 2

Antimetabolites

Answer 2

methotrexate,5-FU,cytarabine,6-MP,6-TG,Fludarabine

Question 3

anticancer antibiotics

Answer 3

doxorubicin
daunorubicin
actinomycin D
mitomycin C

Question 4

Platinum drugs

Answer 4

Cisplatin, Carboplatin, Oxaliplatin

Question 5

Tyrosine kinase inhibitors

Answer 5

Imatinib, Gefitinib

Question 5

Epipodophyllotoxins

Answer 5

Etoposide, Teniposide

Question 6

Camptothecins

Answer 6

Topotecan, Irinotecan

Question 7

Vinca alkaloids

Answer 7

Vincristine, Vinblastine

Question 8

Taxanes

Answer 8

Paclitaxel, Docetaxel

Question 9

GnRH analogues:

Answer 9

Buserelin, abarelix

Question 10

Corticosteroids

Answer 10

Dexamethasone, Prednisolone

Question 11

Estrogen receptor antagonist

Answer 11

Tamoxifen, Fulvestrant

Question 12

Aromatase inhibitor

Answer 12

Letrozole, Anastrozole

Question 13

Antiandrogens

Answer 13

Flutamide, Bicalutamide

Question 14

G1 phase specific drug

Answer 14

L-asparaginase

Question 15

S phase specific drugs

Answer 15

Antimetabolites
* Epipodophyllotoxins
* Camptothecins

Question 16

G2 phase specific drug

Answer 16

Bleomycin

Question 17

M phase specific drugs

Answer 17

Taxanes
*Vinca alkaloids

Question 18

Cell Cycle Non-Specific (CCNS) drugs

Answer 18

kill cells whether they are resting/actively cycling
* Alkylating agents
* Antitumor antibiotics
* Antitumor antibiotics
-Platinum analogues

Question 19

Cyclophosphamide toxicity

Answer 19

hemorrhagiccystitis

Question 20

Doxorubicin toxicity

Answer 20

cardiotoxicity

Question 21

Bleomycin toxicity

Answer 21

pulmonary fibrosis, usually presents as pneumonitis with cough, dyspnea, dry inspiratory crackles on physical examination, and infiltrates on chest x- ray

Question 22

Vincristine toxicity

Answer 22

neuropathy, syndrome of inappropriate antidiuretic hormone secretion

Question 23

Cisplatin toxicity

Answer 23

nephrotoxicity and ototoxicity

Question 24

Methotrexate toxicity

Answer 24

hepatotoxicity and nephrotoxicity, and megaloblastic anemia

Question 25

AML induction

Answer 25

cytarabine + daunorubicin

Question 26

AML maintainance

Answer 26

cytarabine + Daunorubicin/ Etoposide

Question 27

hodgkin lymphoma: ABVD regimen

Answer 27

Doxorubicin,bleomycin,vinblastine,dacarbazine

Question 28

hodgkin lymphoma: MOPP regimen

Answer 28

Mechlorethamine,Vincristine,Procarbazine,Prednisone

Question 29

non-hodgkin lymphoma: CHOP regimen

Answer 29

cyclophosphamide,doxorubicin,vincristine,prednisone