Anticancer drugs Flashcards
(23 cards)
Doc Head and neck tumor
Cisplatin
bladder cancer regimen
cisplatin + gemcitabine
small cell cancer (toc)
cisplatin + etoposide
DOC for esophageal and gastric cancer
Cisplatin
bivalent and quad platinum compounds
cisplatin carboplatin
oxaliplatin
Dose limiting side effect of 5FU
Peripheral neuropathy
ovarian cancer
cis+taxanes
squamous cell cancer
gemcitabine+ cis+ eto+ vinorelbine
Why is oxaliplatin used with 5FU
Blocks thymidylate synthase
Used in colorectal cancer
non scc
cis+eto+vinorelbine+pamitrexed
testicular cancer regimen
BEP bleomycin +etoposide+ plat
regimen for CR cancer
folfox folfirinox
folfiri
Dose limiting toxicity of carboplatin
BM supression
DOC Brain tumor
tenozolamide
doc for colorectal and anal cancer
5 flurouracil
cisplatin side effects
severe NV (doc)
ototoxic
peripheral neuropathy
coasting effect
nephrotoxic (potent)
raynauds
Preload patient with 2L of normal saline
Cl- diuresis causes inactivation of cisplatin + mannitol ( forced diuresis)+ amifostine (radioprotective drug)
4 drug regimen for severe nausea vomiting (doc - ondonsetron)
prostate cancer
GnRH agonist - Goserelin
cisplatin is doc for?
head and neck
brain
urogenital
gastric and oesophageal
osteosacoma
lung cancer
MOA of bleomycin
inhibits topoisomerase 2 s phase
free radical damage g2 phase
not cell cycle specific
Which is cell cycle specific
bleo or plat?
Bleomycin is relatively cell cycle specific
If bleomycin is given in the option with specific phase eg M phase inhibitor then bleo is non specifc
SIDE EFFECTS OF BLEOMYCIN
PULMONARY FIBROSIS
FLAGELLATE DERMATITIS
Uses of bleomycin
AML
Hodgkins ABVD
Testicular BEP
