Anticholinesterase Antagonists Flashcards Preview

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Flashcards in Anticholinesterase Antagonists Deck (24)
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1
Q

RVC drugs

A

Edrophonium

Donepezil

2
Q

RC drugs

A

Neostigminee

Physostigmine

3
Q

IC drugs

A

Malathion

4
Q

Edrophonium uses

A

Diagnosis MG

Tensilon test: distinguish myasthenic crisis from cholinergic crisis

5
Q

SE of edrophonium

A

Only improves myasthenic symptoms

Worsens cholinergic crisis (desensitization, flaccid paralysis)

6
Q

MOA edrophonium

A
  • Quat ammonium
  • bound AChE by weak H and ionic bonds
Does NOT cross BBB
Short Doa (5-10 mint)
7
Q

Donepezil MOA

A

Lipid soluble

Can cross BBB

8
Q

Use of donepezil

A

Cognitive decline in AD

Increase cognition, but NOT disease progression

9
Q

SE donepezil

A

Mild diarrhea
N/V
Bradycardia

10
Q

MOA neostigmine

A
  • quat ammonium
  • some lipid solubility
  • bound to AChE by ionic and reversible covalent bonds

DOA 2 hours
- does NOT cross BBB

11
Q

What is the only inhibitor that is also an agonist at NMJ N receptors??

A

Neostigmine

12
Q

Low neostigmine doses

A

Increase force of contraction

Therapeutic

13
Q

High doses of neostigmine

A

Decrease force of contraction (desensitization)

Toxic

14
Q

Neostigmine use

A

MG therapy

Postop urinary retention
Reverse competitive neuromusclar blockade after surgery

15
Q

SE of neostigmine

A

Excessive M stimulation (N/V, GI cramping, bradycardia) d

Neuromusclar blockade: paralysis of diaphragm at toxic doses

16
Q

What can neostigmine be treated with?

A

Atropine

17
Q

Physostigmine MOA

A

Crosses BBB

Not direct cholinergic agonist

18
Q

Use of physostigmine

A

Treat poisoning by atropine & related drugs that block M blockade

Reverses both peripheral & CNS effects

19
Q

SE of physostigmine

A

Blurred vision
Photophobia
Increase IOP

20
Q

Malathion MOA

A

DOA >50h
Prodrug converted to active
Highly toxic metabolite

OP insecticides

21
Q

Use of malathion

A

Head lice

22
Q

SE malathion

A

Common source of accidental and agricultural poisoning

23
Q

Pralidoxime MOA

A

Must be administered before aging occurs

24
Q

Use of pralidoxime

A

Reactivates AChE ONLY at neuromuscular junction