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Psychiatry > Antidepressant Jeopardy > Flashcards

Antidepressant Jeopardy Flashcards

1
Q

Fluoxetine

prozac

A

SSRI

half-life is 1 week

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2
Q

Discontinuation syndrome

A

abruptly stopping SSRI with short t1/2

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3
Q

Serotonin Syndrome

A

HIGH risk if use SSRIs + MAOIs

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4
Q

Paroxetine

paxil

A

SSRI
AE - weight gain
short T1/2
tapered to be discontinued

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5
Q

washout period from MAOI to SSRI

A

2 weeks

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6
Q

escitalopram

lexapro

A

SSRI

S-enantiomer of citalopram

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7
Q

Fluvoxamine

luvox

A

SSRI
short T1/2
tapered to be discontinued

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8
Q

SSRI AE

A

sexual side effect (specifically ask)

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9
Q

desvenlfaxine

pristiq

A

SNRI

psychoactive metabolite of another SNRI

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10
Q

venlafaxine

effexor

A

SNRI
(any dose blocks serotonin reuptake)
at HIGH dose (>375mg/d) books DOPAMINE reuptake

dose dependent
AE - sweating, INC BP

TX perimenopausal women x hot flashes/flushes

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11
Q

Duloxetine

cymbalta

A

SNRI

tx: painful sx of depression or diabetic neuropathy pain

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12
Q

poop-out syndrome

relapse

A

patients take SSRI/SNRI’s Have an initial response, continue taking the medication but then experience this

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13
Q

SNRIs AE

A

induced bipolar state

agitation, activation

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14
Q

Bupropion

wellbutrin

A

NDRI

TX craving of nicotine (smoking cessation), hypersomnia (>10hrs/nite), ADHD
NOT x anxiety disorder

CAE - Seizures (.4 - 4% at high doses)
NO sexual dysfunction
DEC or not change weight

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15
Q

Onset of action

A

2-4 weeks

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16
Q

NaSSA

A

Noradrenergic and Specific Serotonergic Agent

MOA - pre-synaptic alpha 2 adrenergic antagonist

Dec GI side effects from SSRI/Venlafaxine

17
Q

Mirtazepine

remeron

A

NaSSA class

AE - weight gain

18
Q

Mirtazapine + MAO-I

A

at same time or within 2 weeks INC risk Serotonin Syndrome

19
Q

Onset of therapeutic effect on insomnia and anxiety

A

almost immediately

20
Q

Nortriptyline

pamelor

A

TCA
secondary amine
(metabolized from tertiary amitriptyline)

2nd line - smoking cessation (bc AE)

21
Q

TCAs AE

A

ANTI-cholinergic - BV, urinary hesitancy, dry mouth, constipation

ANTI -a-adrenergic-1 - dizzy, sedation, hypotension

ANTI- Histamine (H1) - sedation, weight gain

Block Na channels - cardiac arrhythmia :(

22
Q

Desipramine

norpramin

A

TCA
secondary amine
(metabolized from tertiary imipramine)

23
Q

TCAs better than SSRI in?

A

tx depression in men

24
Q

CYP450 INhibitors

A

INC TCA’s concentration

Bupropion
Duloxetine
Fluoxetine
Paroxetine

25
Q

TCAs - MOA

A

TX - depression by SNRI

Psychiatry (9 decks)

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