Antidepressants

Question 1

What class of drug is Fluxetine?

Answer 1

SSRI

Question 2

What class of drug is Paroxetine?

Answer 2

SSRI

Question 3

What class of drug is Atomoxentine?

Answer 3

SSRI

Question 4

What class of drug is Citalopram?

Answer 4

SSRI

Question 5

What class of drug is Escitalopram?

Answer 5

SSRI

Question 6

What is the mechanism of action of SSRIs?

Answer 6

inhibit reuptake of serotonin

Question 7

Adverse effects of Fluxetine include cardiovascular and suicide risk in the elderly as well as anorexia in the first few months of use

Answer 7

true

Question 8

SSRIs A/E:

Answer 8

N & V, D, anxiety, restlessness, insomnia, sexual dysfunction

Question 9

What class of drug is Venlafaxine?

Answer 9

SNRIs

Question 10

What class of drug is Desvanlafaxine?

Answer 10

SNRIs

Question 11

What class of drug is Duloxetine?

Answer 11

SNRIs

Question 12

SNRIs mechanism of action?

Answer 12

prevent reuptake of serotonin, NE and DA

Question 13

A/E of SSRIs

Answer 13

N, D, anxiety, restlessness, insomnia, sexual dysfunction, increased BP & HR, orthostatic hypotension

Question 14

What class of drug is Imipramine?

Answer 14

TCA

Question 15

What class of drug is Clomipramine?

Answer 15

TCA

Question 16

What class of drug is Amitriptyline?

Answer 16

TCA

Question 17

What class of drug is Amoxapine?

Answer 17

TCA

Question 18

What class of drug is Doxepin?

Answer 18

TCA

Question 19

What class of drug is trimipramine?

Answer 19

TCA

Question 20

What class of drug is Mirtazapine?

Answer 20

TCA

Question 21

What class of drug is Mianterin?

Answer 21

TCA

Question 22

What is the mechanism of action of TCAs?

Answer 22

Prevent the reuptake of serotonin and NE

Question 23

A/E of TCAs

Answer 23

N, D, anxiety, restlessness, insomnia, sexual dysfunction, increased BP & HR, orthostatic hypotension

Question 24

What class of drug is Tranylcypromine?

Answer 24

MOI

Question 25

What class of drug is Moclobemide?

Answer 25

MOI

Question 26

What class of drug is phenelzine?

Answer 26

MOI

Question 27

What drug class had this MOA? inhibit the oxidative deamination of NA, DA and serotonin

Answer 27

Monoamine oxidase Inhibitors (MOI)

Question 28

What drug class has these adverse effects? Sedation, postural hypotension (sympathetic block), insomnia, impotence, anxiety, restlessness, confusion

Answer 28

MOI

Question 29

What is the mechanism of action of action of Bupropion?

Answer 29

inhibit the reuptake of NE and dopamine

Question 30

What are the A/E of bupropion?

Answer 30

N & V, headaches, activation, agitation, hypertension and insomnia (less sexual dysfunction)

Question 31

Which drug do these contraindications belong to? Risk for seizures, seizure disorder, history of anorexia or bulimia, using or withdrawing from alcohol or benzos

Answer 31

Bupropion

Question 32

Mirtazapine has no action at histamine receptors

Answer 32

False. Mitrazapine antagonizes adrenergic, 5-HT2, 5-HT3 receptors- increased NE and 5-HT. Also has activity at histamine receptors

Question 33

What drug has these contraindications? Pregnancy, lactation, <18 yrs, MAOIs

Answer 33

Mirtazapine

Question 34

A/E of Mirtazapine

Answer 34

Sedation, weight gain, constipation, dry mouth, appetite Decreased risk for sexual dysfunction compared to SSRIs

Question 35

Trazadone MOA?

Answer 35

Inhibit serotonin reuptake

Question 36

Contraindications for trazadone?

Answer 36

Alcohol or hypnotics intoxication, acute MI, < 18 yrs

Question 37

A/E of trazadone

Answer 37

Sedation, N, sexual dysfunction and orthostatic hypotension

Question 38

What drug has a similar MOA to trazadone?

Answer 38

Nefazodone

Question 39

What is the first line drug for depression?

Answer 39

Nefazodone

Question 40

What are the adverse effects of Nefazodone?

Answer 40

Dry mouth, nausea, constipation, visual alterations, orthostatic hypotension, sedation Hepatic failure- most common