Antidepressants Flashcards by Lindsey Dutton

What are the SSRI medications

Fluoxetine
Paroxetine
Sertraline
Citalopram
Escitalopram
Fluvoxamine

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What is the MOA of SSRI

selectively block neuronal reuptake of seratonin
this increases the synaptic concentration and increases the activation of post-synaptic 5-HT receptors

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What is the use of Fluoxetine

Major depression
Bipolar Disorder
OCD
Panic Disorder
Bulemia

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What are the SE of Fluoxetine

sexual dysfunction
Nausea
Headache
Nervousness
Insomnia
Anxiety
Weight gain
Serotonin Syndrome

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What are the uses for Paroxetine

Major Depression

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What is the MOA of Paroxetine

selectively block neuronal reuptake of serotonin- increases activation of post synaptic 5-HT receptors

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what are the SE of Paroxetine

Nausea
Insomnia
HA
Nervousness
weight gain
sexual dysfunction
hyponatremia
GI bleed

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What are the uses of Sertraline

Major Depression

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What is the MOA for Sertraline

selectively block neuronal reuptake of serotonin - increase activation of post synapti 5-HT receptors

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What are the SE of Sertraline

Nausea, Insomnia, HA, nervousness, Weight gain, Sexual dysfunction, hypnatremia, GI bleed

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what are the uses of Citalopram

Major Depression

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What is the MOA of Citalopram

selectively block neuronal re-uptake of serotonin- increase post synaptic serotonin receptors

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What are the SE of Citalopram

Nausea, Insomnia, Nervousness, Weight gain, Sexual dysfunction, GI bleed, Hyponatremia

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What is the use of Escitalopram

Major Depression

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What is the MOA of Escitalopram

selectively block the reuptake of serontonin - increase activation of post synaptic serotonin receptors

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what are the SE of Escitalopram

Nausea, insomnia, Nervousness, Headache, weight gain, sexual dysfunction, hyponatremia, Gi bleed

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What are the uses of Fluvoxamine

Off label for Major Depression

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What is the MOA of Fluvoxamine

selectively block neuronal reuptake of serotonin - increase activation of post synaptic serotonin receptors

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what are the SE of Fluvoxamine

nausea, insomnia, headache, nervousness, sexual dysfunction, hyponatremia, GI bleed, weight gain

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What are the SNRI’s

Duloxetine
Venlafaxine
Desvenlafaxine

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What is the use of Duloxetine

Major Depression
GAD
Chronic pain

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What is the MOA of Duloxetine

block neuronal reuptake of serotonin and norepinephrine with minimal affect on other transmitters or receptors

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What are the SE of Duloxetine

Nausea, HA, Anorexia, nervousness, sweating, somnolence, and insomnia
dose-related weight loss
diastolic hyptensions

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what are contraindications for Duloxetine

combo use with MAOI’s
neonatal withdrawal syndrome and regular withdrawal syndrome

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what are the uses for Venlafaxine

1st for major depression GAD Social Anxiety Panic Disorder Depressive episodes for Bipolar disorder

what is the MOA of Venlafaxine

Block neuronal reuptake of 5HT and NE

what are the SE of Venlafaxine

Nausea, HA, anorexia, nervousness, sweating, insomnia dose-related weight loss diastolic hypertension

what are contraindications for Venlafaxine

Combo use with MOAI's neonatal/withdrawl syndromes

what are the uses for desvenlafaxine

major depression off label for panic disorder, social phobias, GAD and chronic pain

What is the MOA of Desvenlafaxine

Blocks neuronal reuptake of 5HT and NE

what are the SE of desvenlafaxine

Nausea, HA, Anorexia, nervousness, sweating, insomnia Dose-related weight loss Diastoic hypertension

What are contraindications for Desvenlafaxine

Combo use with MAOI's neonatal/withdrawal syndromes

What are the TCA's

Amytriptyline Imiprimine Nortriptyline Despiramine

What are the uses of Amytriptyline

second line for Major Depression fibromyalgia, neuroleptic pain, chronic insomnia, ADHD, panic disorder and OCD

What is the MOA of Amytriptyline

Non-selective: blocks neuronal reuptake of NE and 5HT also cause direct blockade for histamine and Ach

what are the SE of Amytriptyline

orthostatic hyptension, sedation, dry mouth, blurred vision, photophobia, constipation, urinary retention, tachycardia

What are the risks of amytriptyline

seratonin syndrome cardiotoxicity - increase seizure risk OD = life threatening

What are Drug interactions with TCAs

MAOIs sympathomimetics anticholinergics CNS depressants

What are the uses for Impiramine

Second line for Major depression fibromyalgia, neuroletpic pain, chronic insomnia, ADHD, panic disorder, OCD

What is the MOA of imipramine

non-selective: block neuronal reuptake of NE and 5HT also cause direct blockade of receptors for histamine and Ach

What are the SE of Imiprimine

orthostatic hypotension, sedation, cholonergic effects, tachycardia

What are risks of Imiprimine

Seratonin syndrome cardiotoxicity - increase seizure risk OD = life threatening

What are the uses of Norytriptyline

secondary TCA second line for Major depression fibromyalgia, neuroleptic pain, chronic insomnia, ADHD, OCD, panic disorder

What is the MOA of Norytriptyline

Selective: Block neuronal reuptake of NE NOT 5HT also causes direct blockake of histamine and Ach receptors

What are the SE of Norytriptyline

orthostatic hypotension, sedation, cholinergic effects, tachycardia

What are the uses of Despiramine

secondary TCA secondary for Major depresion also used for fibromyalgia, euroleptic pain, chronic insomnia, ADHD, OCD and panic disorder

what is the MOA of Despiramine

selective: blocks neuronal reuptake of NE NOT 5HT also causes direct blockade of histamine and Ach receptors

what are the SE of Despiramine

orthostatic hypotension, sedation, cholinergic effects, tachycardia

what are risks for Norytriptyline and Despiramine

Seratonin syndrome Cardiotoxicity - increase seizure risk OD = life threatening

What are the MAOI medications

Selegiline Phenelzine

what are the uses of Selegiline

LAST RESORT DRUG

what is the MOA of Selegiline

irreversible non-selective MAOI afffecting NE, DA and 5HT.

what are the AE of Selegiline

Food and other drug interactions: Tryamine (cheeses), sympathomimetic drugs weight gain orthostatic hypotension insomnia sexual dysfunction narrow TI

What is the use of Phenelzine

Last resort drugs

what is the MOA of Phenelzine

irreversible non-selective affecting NE, DA and 5HT

What are AE of Phenelzine

tyramine interaction, sympathomimetic drugs, weight gain, orthostatic hypotension, insomnia, sexual dysfunction, narrow TI **Hepatotoxicity**

What are the Atypical antidepressants medications

Bupropion Mirtazapine Trazadone

what is the MOA of Buproprion

does not have direct serotonergic effects

what are SE of bupropion

may cause anxiety does not have sexual dysfunction affects

what is the MOA of Mirtazapine

unique presynaptic MDA increase release of NE and 5HT antihistamine effects

what are the SE of mirtazapine

Weight gain less sexual dysfunction

what are the SE of Trazadone

too sedating to tolerate in full antidepressant dose commonly used in lower doses as hypnotic