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Antidepressants Flashcards

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1
Q

Mood stabilisers ( normontimic agents) are

A

Lithium ,carbamazepine,valproic acid ,Lamotrigine

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2
Q

Non cyclic monoamine reuptake inhibitors (NMARI) or tricyclic antidepressants are

A

Amitriptyline

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3
Q

selective serotonin reuptake inhibitors are

A

Paroxetine,citalopram,sertraline

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4
Q

Selective serotonin and norepinephrine reuptake inhibitors (SSNRI)are

A

Duloxetine and venlafaxine

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5
Q

Noradrenergic and specific serotininergic antidepressants (NaSSA) or tetracyclic antidepressants are

A

Mirtazapine

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6
Q

Selective dopamine and norepinephrine reuptake inhibitors are

A

Bupropion

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7
Q

Benzodiazepines are

A

Diazepam,alprazolam and midazolam

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8
Q

Non benzodiazepines are

A

Phenobarbital

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9
Q

Benzodiazepines analog

A

Zolpidem

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10
Q

Mood stabilisers are used for

A

Prophylactic purpose

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11
Q

Coanalgesia

A

Antidepressants used for enhance analgesic effect

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12
Q

In BD ,which signal transduction mechanism are affected

A

Intercellular and intracellular

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13
Q

Which signal transduction paths are affected by Li

A

IP3 signal path and Wnt signal path

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14
Q

Prerequisite for Li therapy is

A

Adequate renal fn

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15
Q

SE of Li

A

Tinnitus, aphasia, hypothyroidism, visual disturbance ,inhibit action of ADH in kidney

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16
Q

Tricyclic antidepressants have

A

Coanalgesic effect,so used in chronic neuropathic pain

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17
Q

Use of Tricyclic antidepressants (NMRI)

A

Major depression and chronic neuropathic pain

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18
Q

Tricyclic antidepressants overdose cose

A

Cardiotoxicity, convulsions and coma

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19
Q

Contraindications for tricyclic antidepressants are

A

Glaucoma

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20
Q

Effects of SNRI

A

Antidepressants,anxiolytic and coanalgesic

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21
Q

Use of SNRI

A

Major depression, chronic neuropathic pain, generalized anxiety disorder

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22
Q

SE of SNRI

A

Nausea, vomiting and sexual dysfunction

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23
Q

Duloxetine is a

A

SNRI(antidepressant and coanalgesic and anxiolytic)

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24
Q

Venlafaxine is a

A

SNRI(Antidepressants anxiolytic and coanalgesic )

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25
SSRI use
major depression,panic and anxiety,OCD, Phobias
26
SE of SSRI
Nausea, vomiting and sexual dysfunction
27
SSRI can cause
Serotonin syndrome with MAOI and hemorrhage with new gen anticoagulants
28
SERT inhibition is done by
Tricyclic antidepressants,SSRI,SNRI
29
NET inhibition is done by
Tricyclic antidepressants,,SNRI, SDNRI,NaSSA
30
Anticholinergic effect
Amitriptyline (Tricyclic antidepressants)
31
Sedation is seen in
Tricyclic and tetracyclic AD(Amitriptyline,Bupropion)
32
Serotonin syndrome is caused by
SSRI,SSNRI,and Mirtazapine in less than 12 hours
33
MAO inhibitor is
Selegiline
34
Serotonin syndrome is caused by
Drug interactions
35
Drug interacted to cause serotonin syndrome
Tryptophan, amphetamine,triptanes,MAO inhibitor selegiline
36
Symptoms triad of serotonin syndrome
Hyperreflexia, neuromuscular disorders (tremor, rigidity),mental disorders
37
Effects of ANS in serotonin syndrome
Tachycardia, tremor, hyperthermia, mydriasis, sweating
38
Serotonin syndrome has
Hyperreflexia and mydriasis
39
NMS has
Hyporeflexia and unchanged pupil
40
Benzodiazepines are
Positive GABA modulator
41
Flumazenil are
Negative GABA modulator
42
BZD is
Anxiolytic
43
BZD can cause
Thrombophlebitis
44
Flumazenil is
BZD antagonist
45
Diazepam effect
Anxiolytic,sedative,hypnotic,muscle relaxant, anticonvulsant
46
Diazepam indication
Premedication of surgical procedures, seizures,muscle spasms, anxiety (sleep disorders)
47
SE of Diazepam
Anterograde amnesia, respiratory depression, drowsiness
48
Short acting BZD(1.5 to 2.5 h T1/2
Midazolam
49
Use of midazolam
Introductory anesthesia, premedication of diagnostic and therapeutic procedures, seizures
50
Effects of alprazolam
Anxiolytic, sedative, hypnotic, muscle relaxant
51
Alprazolam use
Panic attack and anxiety, stress symptomatic therapy
52
CI of alprazolam is
Driving
53
Problems of BZD therapy
Addiction (within 2 tob3weeka upto 1 to 3 years, rebound effect, tolerance (after 1 month of treatment)
54
Barbiturates are
Hypnotic or sedatives
55
Barbiturates dependence leads to
Barbituromania
56
Barbiturates act on
Beta subunit of GABAA
57
BZD acts on
Alpha subunits 1-5 of GABAA
58
Phenobarbital use
Cardiac neurosis,vegetative agitation,sleep disorders and epilepsy
59
Benzodiazepines analog
Group z
60
BZD analogy are
Zolpidem,acts only on alpha 1 subunit of GABAA
61
Group z drugs have
Mainly hypnotic effect,mild muscle relaxant and antiepileptic activity,no anxiolytic effect
62
Group z, zolpidem used for
Short term treatment for sleep disorders
63
Zolpidem (group z)SE
Somnambulism (sleep walking) and hallucinations
64
Hypnotic or sedatives overdose (BZD and analogue can be treated by
Flumazenil
65
CNS depressients are potentiated by
Alcohol
66
CI of carbamazepine is
Pregnancy
67
Carbamazepine use
Generalized epilepsy, bipolar disorders, neuropathy
68
Carbamazepine blocks
Voltage gated sodium or calcium channel and decrease excitation
69
Carbamazepine is a
Mood stabilisers and antiepileptic agents
70
Valproic acid is an
Antiepileptic agents and mood stabilisers
71
Moa of valproic acid
Blocks voltage gated sodium and calcium channel, inhibit GABA transaminase,inhibit excitation, anticonvulsant,mood stabilisers
72
Use of valproic acid
Epilepsy, bipolar disorders and migraine prophylaxis
73
CI of valproic acid
Pregnancy
74
Lamotrigine (antiepileptic and normontimic) action
Blocks sodium and calcium channel, decrease excitation
75
Use of valproic acid
Epilepsy and bipolar disorders
76
Depressive symptoms should be present for atleast
2weeks
77
Contraindications of amitriptyline and nortriptyline
Glaucoma
78
Epilepsy control agents
Carbamazepine, valproic acid, Lamotrigine,Gabapentin,Ethosuximide, phenobarbital,levetoracetam,Topiramate
79
Medication to treat seizures
Diazepam,midazolam, valproic acid, phenobarbital, levetiracetam,,lorazepam

Antidepressants (1 decks)

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