Antidepressants Flashcards
(34 cards)
What are the major long term side effects of antidepressants?
Sexual dysfunction
Anticholinergic effectives
What is a ‘manic switch’
When bipolar patients become manic and antidepressants can precipitate mania
Symptoms of discontinuation syndrome
irritability
nausea
electric zaps
Symptoms of serotonin syndrome
Restlessness
Tremor
Convulsions
Preferred SSRI in adolescents
Fluoxetine
Preferred SSRI post-MI
Sertraline
SSRI with risk of QT elongation
Citalopram
SNRI with short 1/2 life and severe discontinuation syndrome
Venlafaxine
NA Side effects
sweating
HTN
Why can tricyclic antidepressants be fatal
CVS effects - tachycardia, postural hypotension, slow cardiac conduction
TCA SE
CVS - prolonged QT, arrythmias
Anticholinergic - dry mouth, constipation, blurred vision
Antihistaminergic - sedation, weight gain, dizziness
A1 - postural hypotension
Why are MAOI’s not used
Cheese reaction
What is the cheese reaction
MAOIs combined with tyramine-rich food causes hypertensive crisis
What food to avoid on MAOIs
wine, nuts, soft cheese
Fluoxetine MoA
SSRI
Fluoxetine SE
sexual dysfunction
weight gain
emotional blunting
Sertraline SE
GI upset
Escitalopram complications
Qt prolongation
Citalopram CI
> 60
hepatic impairment
slow metabolizers
Why is Paroxetine CI in pregnancy
causes cardiac malformations in newborns
Paroxetine SE
significant drug interactions
high risk of withdrawal
What non-psychiatric illness does Duloxetine treat
chronic pain
fibromyalgia
diabetic neuropathy
Duloxetine MoA
SNRI
Duloxetine common SE
NA - sweating, HTN
Serotonin - weight gain, sexual dysfunction, anticholinergic, prolonged QT
